Sheng Z M, Guerin M, Gabillot M, Spielmann M, Riou G
Laboratoire de Pharmacologie Clinique et Moléculaire, Institut Gustave Roussy, Villejuif, France.
Oncogene Res. 1988 Feb;2(3):245-50.
Analysis of the c-Ha-ras-1 locus for restriction fragment length polymorphism was determined by Southern blot hybridization in 112 specimens of primary breast carcinoma. Normal cell samples were lymphocytes obtained from 61 of these breast cancer patients and from 62 healthy donors. Our data indicate that the distribution of c-Ha-ras-1 alleles in breast carcinoma patients did not significantly differ from that found in normal individuals. In addition the loss of one allele detected in 5 tumor samples was not correlated to the aggressiveness of breast cancer. Consequently our data imply that hereditary predisposition to breast cancer is not associated with the c-Ha-ras-1 polymorphism as previously reported.
通过Southern印迹杂交对112例原发性乳腺癌标本进行c-Ha-ras-1基因座的限制性片段长度多态性分析。正常细胞样本是从61例乳腺癌患者以及62名健康供体中获取的淋巴细胞。我们的数据表明，乳腺癌患者中c-Ha-ras-1等位基因的分布与正常个体中的分布没有显著差异。此外，在5个肿瘤样本中检测到的一个等位基因的缺失与乳腺癌的侵袭性无关。因此，我们的数据表明，乳腺癌的遗传易感性与先前报道的c-Ha-ras-1多态性无关。
