Department of General and Laboratory Medicine, Mie Prefectural General Medical Center, Yokkaichi, Japan.
Associated Department with Mie Graduate School of Medicine, Tsu, Japan.
Clin Appl Thromb Hemost. 2020 Jan-Dec;26:1076029620912027. doi: 10.1177/1076029620912027.
The activated partial thromboplastin time (APTT)-clot waveform analysis (CWA) was previously reported to be associated with the early detection of disseminated intravascular coagulation and was also reported to be able to measure very low levels of coagulation factor VIII activity. The software program for the analysis for the APTT-CWA allows the associated first and second derivative curves (first and second DCs) to be displayed. The first and second DC reflect the velocity and acceleration, respectively. The height of the first DC reflects the "thrombin burst" and bleeding risk, while that of the second DC is useful for detecting any coagulation factor deficiency and abnormal enhancement of coagulation by phospholipids. Activated partial thromboplastin time-CWA aids in making a differential diagnosis which is difficult to do using only the routine APTT. The CWA is currently used for many applications in the clinical setting, including the monitoring of hemophilia patients and patients receiving anticoagulant therapy and the differential diagnosis of diseases.
活化部分凝血活酶时间（APTT）-凝块波形分析（CWA）先前被报道与弥散性血管内凝血的早期检测相关，并且据报道还能够测量非常低水平的凝血因子 VIII 活性。用于 APTT-CWA 分析的软件程序允许显示相关的一阶和二阶导数曲线（一阶和二阶 DC）。一阶和二阶 DC 分别反映速度和加速度。一阶 DC 的高度反映了“凝血酶爆发”和出血风险，而二阶 DC 的高度则有助于检测任何凝血因子缺乏和磷脂异常增强的凝血。活化部分凝血活酶时间-CWA 有助于做出鉴别诊断，而仅使用常规 APTT 则难以进行鉴别诊断。CWA 目前在临床环境中有许多应用，包括监测血友病患者和接受抗凝治疗的患者以及疾病的鉴别诊断。
