甘油三酯和葡萄糖（TyG）指数与亚临床心肌损伤的关系。
Association between Triglyceride and glycose (TyG) index and subclinical myocardial injury.
机构信息
Department of Cardiology, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
Department of General Medicine, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, China.
出版信息
Nutr Metab Cardiovasc Dis. 2020 Oct 30;30(11):2072-2076. doi: 10.1016/j.numecd.2020.06.019. Epub 2020 Jun 28.
BACKGROUND AND AIMS
Triglyceride and glycose (TyG) index has been viewed as a reliable surrogate of cardiovascular disease (CVD) risk. We hypothesized that elevated TyG index is associated with increased risk of subclinical myocardial injury (SC-MI).
METHODS AND RESULTS
A total of 6093 participants without history of CVD were extracted from the third National Health and Nutrition Examination Survey (NHANES III). SC-MI was defined by cardiac infarction/injury score (CIIS) ≥10. Multivariate logistic regression was performed to examine the association between TyG index (as a qualitative or quantitative variable) and SC-MI. TyG index was positively correlated with CIIS (β = 0.54; p = 0.004) in the multivariable linear regression analysis. In a multivariable model, TyG index was independently associated with an increased risk of SC-MI (OR = 1.17, 95% CI: 1.05 to 1.30; p = 0.004). Also, TyG>9.00 increased the risk of SC-MI (OR = 1.21, 95% CI: 1.03 to 1.43; p = 0.024) independent of other risk factors.
CONCLUSION
Elevated TyG index increases the risk of CIIS and SC-MI, which could be a new biomarker in the clinical practice.
背景与目的
甘油三酯和葡萄糖（TyG）指数已被视为心血管疾病（CVD）风险的可靠替代指标。我们假设升高的 TyG 指数与亚临床心肌损伤（SC-MI）的风险增加相关。
方法和结果
从第三次全国健康和营养检查调查（NHANES III）中提取了 6093 名无 CVD 病史的参与者。SC-MI 通过心肌梗死/损伤评分（CIIS）≥10 定义。多变量逻辑回归用于检查 TyG 指数（作为定性或定量变量）与 SC-MI 之间的关联。在多变量线性回归分析中，TyG 指数与 CIIS 呈正相关（β=0.54；p=0.004）。在多变量模型中，TyG 指数与 SC-MI 的发生风险独立相关（OR=1.17，95%CI：1.05 至 1.30；p=0.004）。此外，TyG>9.00 独立于其他危险因素增加了 SC-MI 的风险（OR=1.21，95%CI：1.03 至 1.43；p=0.024）。
结论
升高的 TyG 指数增加了 CIIS 和 SC-MI 的风险，这可能是临床实践中的一个新的生物标志物。
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