Department of Ophthalmology, Taipei Veterans General Hospital.
Department of Dermatology, Wan Fang Hospital, Taipei Medical University.
J Nutr Sci Vitaminol (Tokyo). 2020;66(4):386-388. doi: 10.3177/jnsv.66.386.
We aimed to examine the correlations between vitamin D deficiency, severity of dry eye symptoms and primary Sjögren's syndrome (pSS) by performing a systematic review and meta-analysis. Online databases (PubMed, Cochrane Library, and Embase) were searched to identify controlled studies comparing (1) severity of dry eye symptoms between participants with and without vitamin D deficiency; and (2) serum vitamin D levels between patients with and without pSS. Eighteen studies were included. Overall, individuals with vitamin D deficiency had shorter tear breakup time (TBUT), lower Schirmer's test scores and higher ocular surface disease index (OSDI) score than those without vitamin D deficiency. Additionally, serum vitamin D levels were found to be lower in pSS than controls. Our findings highlight the importance of vitamin D deficiency in the severity of dry eye symptoms and pSS.
我们旨在通过系统评价和荟萃分析来研究维生素 D 缺乏症、干眼症状严重程度和原发性干燥综合征 (pSS) 之间的相关性。在线数据库（PubMed、Cochrane Library 和 Embase）中进行了检索，以确定比较（1）维生素 D 缺乏症患者与非维生素 D 缺乏症患者之间干眼症状严重程度的对照研究；（2）pSS 患者与无 pSS 患者之间的血清维生素 D 水平。纳入了 18 项研究。总体而言，与非维生素 D 缺乏症患者相比，维生素 D 缺乏症患者的泪膜破裂时间 (TBUT) 更短，Schirmer 试验评分更低，眼表疾病指数 (OSDI) 评分更高。此外，pSS 患者的血清维生素 D 水平低于对照组。我们的研究结果强调了维生素 D 缺乏症在干眼症状和 pSS 严重程度中的重要性。
