Kusaba Yusaku, Izumi Shinyu, Takasaki Jin, Suzuki Manabu, Katagiri Daisuke, Katsuno Takashi, Matsumoto Shuichiro, Sakamoto Keita, Hashimoto Masao, Ohmagari Norio, Katano Harutaka, Suzuki Tadaki, Hojo Masayuki, Sugiyama Haruhito
Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan.
Department of Nephrology, National Center for Global Health and Medicine, Japan.
Intern Med. 2020 Oct 1;59(19):2405-2408. doi: 10.2169/internalmedicine.5413-20. Epub 2020 Aug 29.
An 83-year-old man was hospitalized for coronavirus disease 2019 (COVID-19) after a 10-day history of a persistent fever. Chest computed tomography showed extensive non-segmental ground glass opacity. Despite the initiation of lopinavir and ritonavir, respiratory failure progressed. Two days of polymyxin B-immobilized fiber column-direct hemoperfusion (PMX-DHP) with adjunctive corticosteroid prevented his respiratory condition from worsening. For rapidly progressive COVID-19 cases, the early use of PMX-DHP may avoid the need for mechanical ventilation by suppressing local inflammation of the lung.
一名83岁男性在持续发热10天后因2019冠状病毒病（COVID-19）住院。胸部计算机断层扫描显示广泛的非节段性磨玻璃影。尽管开始使用洛匹那韦和利托那韦，但呼吸衰竭仍在进展。两天的多粘菌素B固定纤维柱直接血液灌流（PMX-DHP）联合皮质类固醇治疗防止了他的呼吸状况恶化。对于快速进展的COVID-19病例，早期使用PMX-DHP可能通过抑制肺部局部炎症避免机械通气的需要。
