Department of Pulmonary Medicine/Infection and Oncology, Internal Medicine, Nippon Medical School, Tokyo, Japan. sabe @ nms.ac.jp
Blood Purif. 2011;32(4):310-6. doi: 10.1159/000330325. Epub 2011 Sep 2.
BACKGROUND/AIM: Recent reports suggest that polymyxin B (PMX)-immobilized fiber may have beneficial effects in idiopathic pulmonary fibrosis (IPF) with acute exacerbation (AE). High mobility group box-1 (HMGB-1) is an important pro-inflammatory mediator that contributes to acute lung inflammation. This study was aimed to investigate whether PMX treatment affects serum HMGB-1 levels and oxygenation in IPF patients with AE.
Twenty IPF patients with AE were treated by PMX. PMX treatment was carried out once daily for 2 successive days. Serum HMGB-1 levels were measured before and after PMX treatment. We also monitored arterial oxygen tension (PaO(2))/inspiratory oxygen fraction (FiO(2)) (P/F) ratio. PMX fiber columns were analyzed to examine whether HMGB-1 was absorbed by PMX.
PMX treatment significantly improved both the serum HMGB-1 level and P/F ratio. HMGB-1 was detected in washing medium from the PMX column.
PMX treatment may reduce serum HMGB-1 and improve oxygenation in patients with IPF with AE.
背景/目的：最近的报告表明，多黏菌素 B（PMX）固定纤维可能对特发性肺纤维化（IPF）伴急性加重（AE）具有有益作用。高迁移率族蛋白 B1（HMGB-1）是一种重要的促炎介质，有助于急性肺炎症。本研究旨在探讨 PMX 治疗是否影响 AE 型 IPF 患者的血清 HMGB-1 水平和氧合。
20 例 AE 型 IPF 患者接受 PMX 治疗。PMX 治疗连续进行 2 天，每天 1 次。在 PMX 治疗前后测量血清 HMGB-1 水平。我们还监测了动脉氧分压（PaO2）/吸入氧分数（FiO2）（P/F）比值。分析 PMX 纤维柱以检查 HMGB-1 是否被 PMX 吸收。
PMX 治疗显著改善了血清 HMGB-1 水平和 P/F 比值。从 PMX 柱的洗涤液中检测到 HMGB-1。
PMX 治疗可降低 AE 型 IPF 患者的血清 HMGB-1 水平并改善氧合。
