聚马菌素固定纤维柱降低特发性肺纤维化急性加重患者血清高迁移率族蛋白 B 水平。
Reduction in serum high mobility group box-1 level by polymyxin B-immobilized fiber column in patients with idiopathic pulmonary fibrosis with acute exacerbation.
机构信息
Department of Pulmonary Medicine/Infection and Oncology, Internal Medicine, Nippon Medical School, Tokyo, Japan. sabe @ nms.ac.jp
出版信息
Blood Purif. 2011;32(4):310-6. doi: 10.1159/000330325. Epub 2011 Sep 2.
BACKGROUND/AIM: Recent reports suggest that polymyxin B (PMX)-immobilized fiber may have beneficial effects in idiopathic pulmonary fibrosis (IPF) with acute exacerbation (AE). High mobility group box-1 (HMGB-1) is an important pro-inflammatory mediator that contributes to acute lung inflammation. This study was aimed to investigate whether PMX treatment affects serum HMGB-1 levels and oxygenation in IPF patients with AE.
MATERIALS AND METHODS
Twenty IPF patients with AE were treated by PMX. PMX treatment was carried out once daily for 2 successive days. Serum HMGB-1 levels were measured before and after PMX treatment. We also monitored arterial oxygen tension (PaO(2))/inspiratory oxygen fraction (FiO(2)) (P/F) ratio. PMX fiber columns were analyzed to examine whether HMGB-1 was absorbed by PMX.
RESULTS
PMX treatment significantly improved both the serum HMGB-1 level and P/F ratio. HMGB-1 was detected in washing medium from the PMX column.
CONCLUSION
PMX treatment may reduce serum HMGB-1 and improve oxygenation in patients with IPF with AE.
背景/目的：最近的报告表明，多黏菌素 B（PMX）固定纤维可能对特发性肺纤维化（IPF）伴急性加重（AE）具有有益作用。高迁移率族蛋白 B1（HMGB-1）是一种重要的促炎介质，有助于急性肺炎症。本研究旨在探讨 PMX 治疗是否影响 AE 型 IPF 患者的血清 HMGB-1 水平和氧合。
材料和方法
20 例 AE 型 IPF 患者接受 PMX 治疗。PMX 治疗连续进行 2 天，每天 1 次。在 PMX 治疗前后测量血清 HMGB-1 水平。我们还监测了动脉氧分压（PaO2）/吸入氧分数（FiO2）（P/F）比值。分析 PMX 纤维柱以检查 HMGB-1 是否被 PMX 吸收。
结果
PMX 治疗显著改善了血清 HMGB-1 水平和 P/F 比值。从 PMX 柱的洗涤液中检测到 HMGB-1。
结论
PMX 治疗可降低 AE 型 IPF 患者的血清 HMGB-1 水平并改善氧合。
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