两例间质性肺炎急性加重期患者采用多粘菌素B固定化纤维柱血液灌流治疗。
Two cases of acute exacerbation of interstitial pneumonia treated with polymyxin B-immobilized fiber column hemoperfusion treatment.
作者信息
Noma Satoshi, Matsuyama Wataru, Mitsuyama Hideo, Suetsugu Takayuki, Koreeda Yoshimizu, Mizuno Keiko, Higashimoto Ikkou, Kakihana Yasuyuki, Hashiguchi Teruto, Maruyama Ikuro, Osame Mitsuhiro, Arimura Kimiyoshi
机构信息
Division of Respiratory Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital.
出版信息
Intern Med. 2007;46(17):1447-54. doi: 10.2169/internalmedicine.46.0117. Epub 2007 Sep 3.
The effect of polymixin B-immobilized fiber column (PMX) hemoperfusion treatment for acute exacerbation of interstitial pneumonia (IP) has been reported. Here, we report 2 cases of acute exacerbation of IP successfully treated with PMX hemoperfusion. One is a 55-year-old woman who was diagnosed as microscopic polyangiitis (MPA) with IP. The other is a 58-year-old man, diagnosed as having idiopathic pulmonary fibrosis. Both cases were treated with PMX hemoperfusion and other therapies. One died on day 44 and the other is still alive. The PMX hemoperfusion treatment decreased the serum levels of several cytokines and activated neutrophil percentage in bronchoalveolar lavage fluid.
多黏菌素B固定化纤维柱（PMX）血液灌流治疗间质性肺炎（IP）急性加重期的效果已有报道。在此，我们报告2例经PMX血液灌流成功治疗的IP急性加重期病例。1例为55岁女性，诊断为显微镜下多血管炎（MPA）合并IP。另1例为58岁男性，诊断为特发性肺纤维化。2例均接受了PMX血液灌流及其他治疗。1例于第44天死亡，另1例仍存活。PMX血液灌流治疗降低了几种细胞因子的血清水平，并降低了支气管肺泡灌洗液中活化中性粒细胞的百分比。
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