Busch Andrew M, Louie Mark E, SantaBarbara Nicholas J, Ajayi Alex A, Gleason Neil, Dunsiger Shira I, Carey Michael P, Ciccolo Joseph T
Department of Medicine, Hennepin Healthcare, 715 South 8th Street, Minneapolis, MN 55404, United States.
Department of Medicine, University of Minnesota Medical School, 401 East River Parkway, Minneapolis, MN 55455, United States.
Ment Health Phys Act. 2019 Oct;17. doi: 10.1016/j.mhpa.2019.100299. Epub 2019 Sep 12.
Depression is severely undertreated in Black men. This is primarily because Black men are less likely to seek traditional psychiatric treatment, have less access and more barriers to treatment, and perceive more stigma associated with treatment. Depression contributes to cardiovascular disease (CVD), and Black men have the highest rate of mortality from CVD. Resistance training (RT) can have beneficial effects on both depression and CVD. This study will be the first randomized controlled trial to test the effects of RT on depression and cardiovascular health in a sample of depressed Black men.
METHOD/DESIGN: Fifty Black men with clinically significant symptoms of depression will be randomized to either (a) a 12-week RT or (b) an attention-control group. Behavioral Activation techniques will be used to support adherence to home-based RT goals. Both groups will meet on-site twice/week during the 12-week program, and follow-up assessments will occur at the end-of-treatment and 3 months post-treatment. Qualitative interviews will be conducted after the 3-month follow-up. The objectives of this study are (1) to assess the feasibility and acceptability of recruitment, retention, and intervention procedures, (2) to obtain preliminary evidence of efficacy, and (3) to explore potential mediators of the effects of RT on depression.
This study will advance the field of minority men's health by producing new data on the effects of RT for depression, the potential mechanisms of action that may support its use, and its effects on markers of CVD risk in Black men.
ClinicalTrials.gov (NCT03107039).
黑人男性的抑郁症治疗严重不足。这主要是因为黑人男性寻求传统精神科治疗的可能性较小，获得治疗的机会较少且障碍更多，并且认为治疗带来的耻辱感更强。抑郁症会导致心血管疾病（CVD），而黑人男性的心血管疾病死亡率最高。抗阻训练（RT）对抑郁症和心血管疾病都可能有有益影响。本研究将是第一项随机对照试验，以测试抗阻训练对抑郁的黑人男性样本的抑郁症和心血管健康的影响。
方法/设计：五十名有临床显著抑郁症状的黑人男性将被随机分为（a）为期12周的抗阻训练组或（b）注意力控制组。将使用行为激活技术来支持对家庭抗阻训练目标的坚持。在为期12周的项目中，两组将每周两次在现场会面，并且在治疗结束时和治疗后3个月进行随访评估。在3个月随访后将进行定性访谈。本研究的目的是（1）评估招募、留存和干预程序的可行性和可接受性，（2）获得疗效的初步证据，以及（3）探索抗阻训练对抑郁症影响的潜在中介因素。
本研究将通过提供关于抗阻训练对抑郁症的影响、可能支持其使用的潜在作用机制及其对黑人男性心血管疾病风险标志物的影响的新数据，推动少数族裔男性健康领域的发展。
ClinicalTrials.gov（NCT03107039）。
