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脂肽作为疫苗佐剂：这些多功能载体的新作用。

lipopeptides as vaccine adjuvants: a new role for these versatile carriers.

作者信息

Grippo Lucía Daniela, Reidel Ivana Gabriela, García María Inés, Streu Alexis, Müller Diana María, Veaute Carolina Melania

机构信息

LAQUIMAP, Dto. Química Orgánica, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.

Laboratorio de Inmunología Experimental, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.

出版信息

Clin Exp Vaccine Res. 2020 Jul;9(2):159-163. doi: 10.7774/cevr.2020.9.2.159. Epub 2020 Jul 31.

DOI:10.7774/cevr.2020.9.2.159
PMID:32864372
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7445326/
Abstract

The design of subunit vaccines requires new adjuvant systems. We designed and synthesized new lipopeptides (cysteine-based) of low molecular weight with different hydrophobic chains that dimerize becoming lipopeptides. They were characterized and their adjuvant capacity was tested in mice by the inoculation of a protein antigen formulated with the lipopeptides, with and without the addition of CpG-oligodeoxynucleotides. Formulations were able to induce an immune response and produced no adverse effects. An adjuvant ability is described for the first time for this type of molecules.

摘要

亚单位疫苗的设计需要新的佐剂系统。我们设计并合成了具有不同疏水链的新型低分子量（基于半胱氨酸）脂肽，这些脂肽会二聚化形成脂肽。对它们进行了表征，并通过接种与脂肽配制的蛋白质抗原（添加或不添加CpG - 寡脱氧核苷酸）在小鼠中测试了它们的佐剂能力。这些制剂能够诱导免疫反应且未产生不良反应。首次描述了这类分子的佐剂能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/406c/7445326/d92490f27fcd/cevr-9-159-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/406c/7445326/38f6d6ff1a75/cevr-9-159-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/406c/7445326/d92490f27fcd/cevr-9-159-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/406c/7445326/38f6d6ff1a75/cevr-9-159-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/406c/7445326/d92490f27fcd/cevr-9-159-g002.jpg

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2
Physical Characterization of Gemini Surfactant-Based Synthetic Vectors for the Delivery of Linear Covalently Closed (LCC) DNA Ministrings.用于递送线性共价闭合（LCC）DNA微串的基于双子表面活性剂的合成载体的物理表征
PLoS One. 2015 Nov 12;10(11):e0142875. doi: 10.1371/journal.pone.0142875. eCollection 2015.
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Gemini surfactants from natural amino acids.
天然氨基酸双子表面活性剂。
Adv Colloid Interface Sci. 2014 Mar;205:134-55. doi: 10.1016/j.cis.2013.10.020. Epub 2013 Oct 24.
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Solution properties and emulsification properties of amino acid-based gemini surfactants derived from cysteine.源自半胱氨酸的氨基酸基双子表面活性剂的溶液性质和乳化性质
J Oleo Sci. 2013;62(8):579-86. doi: 10.5650/jos.62.579.
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