Grizard J, Champredon C, Aina E, Sornet C, Debras E
Laboratoire d'Etude du Métabolisme Azoté, INRA Centre de THEIX, Ceyrat, France.
Horm Metab Res. 1988 Feb;20(2):71-6. doi: 10.1055/s-2007-1010756.
The metabolism and action of insulin and glucagon were investigated in goats during mid lactating (50 days postpartum) and during the dry period. The animals were fed hay and concentrate during lactation (1:1) and only hay during dry period. Pulse doses of unlabelled insulin and glucagon were injected intravenously. The disappearance of insulin from the circulation was faster during lactation than during dry period; the metabolic clearance rate of insulin was significantly increased during lactation. In contrast, the kinetic parameters of glucagon disappearance were very similar during the two periods. Basal plasma hormones (i.e. before hormone injection) were higher during lactation than during dry period; the molar ratio insulin:glucagon was left unchanged. The increase in plasma insulin following glucagon-stimulated hyperglycaemia was similar during the two periods. The ability of insulin to elicit a decrease in blood glucose was markedly impaired during lactation when compared to dry period. In contrast the ability of glucagon to increase blood glucose was slightly improved during lactation. Those endocrine changes could be related to the effect of both lactation and diet.
对处于泌乳中期（产后50天）和干奶期的山羊的胰岛素和胰高血糖素的代谢及作用进行了研究。泌乳期给动物饲喂干草和精饲料（比例为1:1），干奶期只喂干草。静脉注射非标记胰岛素和胰高血糖素的脉冲剂量。胰岛素从循环中的消失在泌乳期比干奶期更快；泌乳期胰岛素的代谢清除率显著增加。相比之下，两个时期胰高血糖素消失的动力学参数非常相似。基础血浆激素（即激素注射前）在泌乳期高于干奶期；胰岛素与胰高血糖素的摩尔比保持不变。胰高血糖素刺激的高血糖症后血浆胰岛素的增加在两个时期相似。与干奶期相比，泌乳期胰岛素降低血糖的能力明显受损。相反，泌乳期胰高血糖素升高血糖的能力略有改善。这些内分泌变化可能与泌乳和饮食的影响有关。
