He Miao, Zhou Rouxi, Liu Sen, Cheng Weijing, Wang Wei
Department of Ophthalmology, Guangdong General Hospital, Guangdong Academy of Medical Sciences , Guangzhou, People's Republic of China.
Department of Ophthalmology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha , Hunan, China.
Curr Eye Res. 2021 Mar;46(3):277-283. doi: 10.1080/02713683.2020.1812086. Epub 2020 Aug 30.
To summarize the research status on the function and mechanism of circRNAs in regulating the occurrence of diabetic retinopathy (DR). We systematically searched PubMed, Embase.com, and ARVO Abstracts website and reviewed relevant studies. Thousands of circRNAs were found to be aberrantly expressed in DR patients, animal models, or cell models. A few circRNAs, such as cPWWP2A, circDNMT3B, circHIPK3, circ_0005015, et al were demonstrated to play an important role in DR by regulating the angiogenesis, proliferation, apoptosis, and inflammatory response of various cells in the retina. CircRNAs are involved in the development of DR. CircRNAs can not only serve as DR biomarkers, but also become therapeutic targets for DR. The role of plenty of circRNAs in DR is yet to be discovered.
总结环状RNA（circRNAs）在调节糖尿病视网膜病变（DR）发生中的功能及机制的研究现状。我们系统检索了PubMed、Embase.com和ARVO摘要网站，并对相关研究进行了综述。发现数千种circRNAs在DR患者、动物模型或细胞模型中异常表达。少数circRNAs，如cPWWP2A、circDNMT3B、circHIPK3、circ_0005015等，通过调节视网膜中各种细胞的血管生成、增殖、凋亡和炎症反应，在DR中发挥重要作用。circRNAs参与DR的发展。circRNAs不仅可作为DR的生物标志物，还可成为DR的治疗靶点。大量circRNAs在DR中的作用尚待发现。
