环状 RNA：糖尿病视网膜病变的新靶点。
Circular RNAs: Novel target of diabetic retinopathy.
机构信息
Department of Endocrinology, the First Affiliated Hospital of Harbin Medical University, Harbin, China.
出版信息
Rev Endocr Metab Disord. 2021 Jun;22(2):205-216. doi: 10.1007/s11154-021-09646-0. Epub 2021 Mar 24.
In diabetic patients, diabetic retinopathy (DR) is the leading cause of blindness and seriously affects the quality of life. However, current treatment methods of DR are not satisfactory. Advances have been made in understanding abnormal protein interactions and signaling pathways in DR pathology, but little is known about epigenetic regulation. Non-coding RNAs, such as circular RNAs (circRNAs), have been shown to be associated with DR. In this review, we summarized the function of circRNAs and indicated their roles in the pathogenesis of DR, which may provide new therapeutic targets for clinical treatment.
在糖尿病患者中，糖尿病视网膜病变（DR）是导致失明的主要原因，严重影响生活质量。然而，目前 DR 的治疗方法并不令人满意。人们对 DR 病理中异常蛋白相互作用和信号通路的认识已经取得了进展，但对表观遗传调控知之甚少。非编码 RNA，如环状 RNA（circRNA），已被证明与 DR 有关。在这篇综述中，我们总结了 circRNA 的功能，并指出了它们在 DR 发病机制中的作用，这可能为临床治疗提供新的治疗靶点。
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