Morakote N, Justus D E
Department of Parasitology, Faculty of Medicine, Chiang Mai University, Thailand.
Int Arch Allergy Appl Immunol. 1988;86(1):28-34. doi: 10.1159/000234602.
To a considerable degree, malaria-induced immunosuppression has been attributed to an inhibition of macrophage accessory cell function. In this study hemozoin, a plasmodium hemoglobin degradation product which readily accumulates in phagocytic cells and tissues during infection, was examined for its influence on immune responses. Hemozoin-laden liver and splenic macrophages from Plasmodium berghei-infected mice, displayed accessory cell dysfunction which was likely due to hemozoin loading by these phagocytic cells. This indicated by the observation that hemozoin obtained from livers and spleens of infected mice as well as from Plasmodium falciparum cultures greatly inhibited splenic plaque-forming cell responses to sheep red blood cells. The results of the present study strongly suggest that the inhibition of macrophage accessory cell activity is due, at least in part, to the uptake and accumulation of hemozoin in their cytoplasms.
在很大程度上，疟疾诱导的免疫抑制被归因于巨噬细胞辅助细胞功能的抑制。在本研究中，对疟色素（一种疟原虫血红蛋白降解产物，在感染期间容易在吞噬细胞和组织中积累）对免疫反应的影响进行了研究。来自感染伯氏疟原虫小鼠的载有疟色素的肝脏和脾脏巨噬细胞表现出辅助细胞功能障碍，这可能是由于这些吞噬细胞摄取了疟色素所致。这一点可通过以下观察结果得到证明：从感染小鼠的肝脏和脾脏以及恶性疟原虫培养物中获得的疟色素极大地抑制了脾脏对绵羊红细胞的空斑形成细胞反应。本研究结果强烈表明，巨噬细胞辅助细胞活性的抑制至少部分归因于疟色素在其细胞质中的摄取和积累。
