β，γ-不饱和α-酮酯与香豆素-3-酮的立体选择性铜催化直接羟醛缩合反应
Stereoselective Copper-Catalyzed Direct Aldol Reaction of β, γ-Unsaturated α-Ketoesters with Coumaran-3-Ones.
作者信息
Li Kuiliang, Sun Xiang, Li Linge, Zha Zhenggen, Zhang Feng-Lian, Wang Zhiyong
机构信息
Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Soft Matter Chemistry & Center, for Excellence in Molecular Synthesis of Chinese Academy of Sciences, Collaborative Innovation Center of Suzhou Nano Science and Technology & School of Chemistry and Materials Science, University of Science and Technology of China, Hefei, 230026, P. R. China.
出版信息
Chemistry. 2021 Jan 7;27(2):581-584. doi: 10.1002/chem.202003510. Epub 2020 Oct 27.
An efficient direct aldol reaction between coumaran-3-ones and β, γ-unsaturated α-ketoesters by virtue of a chiral copper complex is developed. A series of coumaran-3-one derivatives containing chiral tertiary alcohol structures are obtained in excellent yields and stereoselectivities.
通过手性铜配合物实现了香豆素-3-酮与β,γ-不饱和α-酮酯之间高效的直接羟醛缩合反应。得到了一系列具有优异产率和立体选择性的含手性叔醇结构的香豆素-3-酮衍生物。
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