Chen Zhi-Hong, Wu Ya-Dong
Dept. of Stomatology, People's Hospital of Guizhou Province, Guiyang 550002, China.
Dept. of Oral and Maxillofacial Surgery, Stomatological Hospital of Guizhou Medical University, Guiyang 550001, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2020 Aug 1;38(4):449-453. doi: 10.7518/hxkq.2020.04.017.
Oral squamous cell carcinoma (OSCC) is a common malignant tumor in the oral and maxillofacial region. At present, the treatment of OSCC is mainly based on surgical oriented comprehensive sequence therapy, especially the triple therapy of surgery, radiotherapy, and chemotherapy. However, the overall five-year survival rate is relatively low. Therefore, researching the pathogenesis and treatment methods of OSCC is important. The immune checkpoint of programmed death receptor-1 (PD-1) and programmed death receptor-1 ligand (PD-L1) have been the focus of research in recent years. Several studies have shown that the high expression of PD-1/PD-L1 in most OSCC microenvironments may contribute to the immune escape of tumors. In this study, the research status of immune checkpoint of PD-1/PD-L1 and its relevant inhibitors in OSCC were reviewed.
口腔鳞状细胞癌（OSCC）是口腔颌面部常见的恶性肿瘤。目前，OSCC的治疗主要基于以手术为主的综合序列治疗，尤其是手术、放疗和化疗的三联疗法。然而，总体五年生存率相对较低。因此，研究OSCC的发病机制和治疗方法具有重要意义。程序性死亡受体1（PD-1）和程序性死亡受体1配体（PD-L1）的免疫检查点是近年来的研究热点。多项研究表明，大多数OSCC微环境中PD-1/PD-L1的高表达可能有助于肿瘤的免疫逃逸。本研究对OSCC中PD-1/PD-L1免疫检查点及其相关抑制剂的研究现状进行了综述。
