Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.
Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
ACS Nano. 2020 Oct 27;14(10):13975-13985. doi: 10.1021/acsnano.0c06388. Epub 2020 Sep 8.
The nanoprobes for identification of cancer metastases in the mononuclear phagocyte system (MPS) organs are of significant importance but are limited due to the long-standing challenge of low tumor-targeting specificity with inadequate targeting efficiency and high nonspecific accumulation. Here, we report a surface regulation strategy that integrates the tumor-acidity-activated charge-reversal behavior and precise control in both hydrodynamic diameter (HD) and surface charge on ultrasmall luminescent gold nanoparticles (AuNPs) to achieve significantly high tumor-targeting specificity. The precise regulation of AuNPs to a rational HD and surface charge could rapidly and selectively recognize small metastatic tumors (∼1 mm) in liver and lung with high signal-to-noise ratios of 4.6 and 4.5, respectively. These results help further understand the transport of nanoprobes and provide guidance for design of translatable nanosized nanomedicines in cancer metastasis theranostics.
用于单核吞噬细胞系统 (MPS) 器官中癌症转移鉴定的纳米探针具有重要意义，但由于肿瘤靶向特异性低、靶向效率不足和非特异性积累高，其应用受到限制。在这里，我们报告了一种表面调控策略，该策略整合了肿瘤酸度激活的电荷反转行为和超小发光金纳米粒子 (AuNP) 上的水动力直径 (HD) 和表面电荷的精确控制，以实现显著的高肿瘤靶向特异性。AuNP 的精确调控到合理的 HD 和表面电荷可以快速和选择性地识别肝脏和肺部的小转移瘤（约 1 毫米），信噪比分别为 4.6 和 4.5。这些结果有助于进一步了解纳米探针的转运，并为癌症转移治疗中可转译的纳米尺寸纳米药物的设计提供指导。
