State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China.
Department of Chemistry, University of Bath, Bath BA2 7AY, U.K.
Anal Chem. 2022 Sep 27;94(38):13189-13196. doi: 10.1021/acs.analchem.2c02717. Epub 2022 Sep 15.
We developed an coordination-driven spatially confined strategy for preparing near-infrared emissive gold nanoclusters encapsulated by fluorinated polymers (AuNCs@PF, λ = 810 nm) with good stability and high quantum yields (27.7%), far higher than those previously reported for NIR AuNCs (>800 nm). Based on the stepwise enhancements including long blood circulation-induced passive tumor targeting, fluoro-enhanced tumor permeation, and tumor microenvironment (weak acid)-induced aggregation retention in cells, these AuNCs demonstrated bright and stable NIR fluorescence imaging ability in tumors. Additionally, the AuNCs@PF were capable of fluorine magnetic resonance imaging and computed tomographic imaging. The multimodal imaging of tumor-bearing mice clearly implied the potential of AuNCs@PF in biomedical fields.
我们开发了一种基于配位驱动的空间受限策略，用于制备由氟化聚合物包裹的近红外发光金纳米团簇（AuNCs@PF，λ=810nm），具有良好的稳定性和高量子产率（27.7%），远高于之前报道的近红外 AuNCs（>800nm）。基于包括长血液循环诱导的被动肿瘤靶向、氟增强的肿瘤渗透以及细胞内弱酸性环境诱导的聚集保留在内的逐步增强，这些 AuNCs 在肿瘤中表现出明亮且稳定的近红外荧光成像能力。此外，AuNCs@PF 还能够进行氟磁共振成像和计算机断层扫描成像。荷瘤小鼠的多模态成像清楚地表明了 AuNCs@PF 在生物医学领域的潜力。
