Assigning Distal Genomic Enhancers to Cardiac Disease-Causing Genes.
作者信息
Anene-Nzelu Chukwuemeka George, Tan Wilson Lek Wen, Lee Chang Jie Mick, Wenhao Zheng, Perrin Arnaud, Dashi Albert, Tiang Zenia, Autio Matias Ilmari, Lim Bram, Wong Eleanor, Tan Hui San, Pan Bangfen, Morley Michael P, Margulies Kenneth B, Cappola Thomas P, Foo Roger S-Y
机构信息
Cardiovascular Research Institute, National University Health System, Singapore (C.G.A.-N., W.L.W.T., C.J.M.L., Z.W., A.P., A.D., Z.T., M.I.A., B.L., E.W., H.S.T., B.P., R.S.-Y.F.).
Genome Institute of Singapore (C.G.A.-N., W.L.W.T., C.J.M.L., Z.W., A.P., A.D., Z.T., M.I.A., B.L., E.W., H.S.T., B.P., R.S.-Y.F.).
出版信息
Circulation. 2020 Sep;142(9):910-912. doi: 10.1161/CIRCULATIONAHA.120.046040. Epub 2020 Aug 31.
Abstract
摘要
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本文引用的文献
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Towards a comprehensive catalogue of validated and target-linked human enhancers.迈向一个全面的已验证和与靶标相关的人类增强子目录。
Nat Rev Genet. 2020 May;21(5):292-310. doi: 10.1038/s41576-019-0209-0. Epub 2020 Jan 27.
2
Activity-by-contact model of enhancer-promoter regulation from thousands of CRISPR perturbations.基于数千个 CRISPR 干扰的增强子-启动子调控的活性-接触模型。
Nat Genet. 2019 Dec;51(12):1664-1669. doi: 10.1038/s41588-019-0538-0. Epub 2019 Nov 29.
3
Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks.人类胚胎干细胞衍生的心肌细胞启动子互作组将 GWAS 区域连接到心脏基因网络。
Nat Commun. 2018 Jun 28;9(1):2526. doi: 10.1038/s41467-018-04931-0.
4
Multi-ethnic genome-wide association study for atrial fibrillation.多民族全基因组关联研究心房颤动。
Nat Genet. 2018 Jun 11;50(9):1225-1233. doi: 10.1038/s41588-018-0133-9.
5
The Genotype-Tissue Expression (GTEx) project.基因型-组织表达 (GTEx) 项目。
Nat Genet. 2013 Jun;45(6):580-5. doi: 10.1038/ng.2653.
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