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巴西阿雷格里港一名接受抗逆转录病毒治疗且病毒载量无法检测的 HIV 阳性女性的 COVID-19 肺炎。

COVID-19 pneumonia in an HIV-positive woman on antiretroviral therapy and undetectable viral load in Porto Alegre, Brazil.

机构信息

Hospital de Clínicas de Porto Alegre, Infectious Diseases Service, Porto Alegre, RS, Brazil.

Hospital de Clínicas de Porto Alegre, Infectious Diseases Service, Porto Alegre, RS, Brazil; Universidade Federal de Rio Grande do Sul, Faculdade de Medicina, Porto Alegre, RS, Brazil.

出版信息

Braz J Infect Dis. 2020 Sep-Oct;24(5):455-457. doi: 10.1016/j.bjid.2020.07.009. Epub 2020 Aug 26.

Abstract

COVID-19 pandemic has been a problem worldwide. It is important to identify people at risk of progressing to severe complications and to investigate if some existing antivirals could have any action against SARS-CoV-2. In this context, HIV-infected individuals and antiretroviral drugs might be included, respectively. Herein we present the case of a 63-year-old HIV-infected woman with undetectable viral load, on dolutegravir, tenofovir and lamivudine, who was hospitalized due to COVID-19 pneumonia. In spite of having some clinical markers of severity on admission, the patient improved and was discharged after a week. To our knowledge, this is the first report of severe SARS-CoV-2 infection in an HIV-infected individual in Brazil.

摘要

新型冠状病毒肺炎(COVID-19)大流行是一个全球性问题。重要的是要识别出有进展为严重并发症风险的人群,并研究是否有一些现有的抗病毒药物对 SARS-CoV-2 有作用。在这方面,可以分别考虑感染艾滋病毒的个体和抗逆转录病毒药物。在此,我们介绍了一位 63 岁的 HIV 感染者的病例,该患者的病毒载量无法检测,服用多替拉韦、替诺福韦和拉米夫定,因 COVID-19 肺炎住院。尽管入院时有一些严重的临床标志物,但患者在一周后得到改善并出院。据我们所知,这是巴西首例 HIV 感染者严重 SARS-CoV-2 感染的报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae7a/9392091/5641f288c201/gr1.jpg

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