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新型冠状病毒肺炎与肺炎并存:放射学诊断及艾滋病毒检测的重要性。

Concurrent COVID-19 and pneumonia: The importance of radiological diagnostic and HIV testing.

作者信息

Anggraeni Amelia Tantri, Soedarsono Soedarsono, Soeprijanto Bambang

机构信息

Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Jl. Mayjen Prof. Dr. Moestopo No. 47 Surabaya, East Java, Surabaya, 60131, Indonesia.

Department of Radiology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.

出版信息

Radiol Case Rep. 2021 Oct 2;16(12):3685-3689. doi: 10.1016/j.radcr.2021.09.002. eCollection 2021 Dec.

Abstract

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has changed the focus of healthcare and become a public health challenge around the world. The coinfection of SARS-CoV-2 with other microorganisms, including fungi, can cause difficult diagnosis and a worse prognosis. pneumonia (PJP) is a common opportunistic infection in human immunodeficiency virus (HIV) patients. However, sometimes the diagnosis is late presented after PJP finding on chest X-ray. We report a 24-year-old man with COVID-19 and PJP. Reverse transcriptase-polymerase chain reaction showed positive for SARS-CoV-2. HIV diagnosis was late presented after PJP finding on chest X-ray examination. HIV serology was positive with an absolute CD4+ count was 16 cells/mm. He was treated with remdesivir IV, methylprednisolone IV, heparin, and cefoperazone-sulbactam IV. He was discharged after being admitted for 25 days. HIV treatment was started in outpatient services. Radiological diagnostic to diagnose concurrent COVID-19 and PJP pneumonia are important, especially in the setting where microscopic examination of sputum or Bronchoalveolar Lavage Fluid (BALF) is not available, or because BAL and sputum induction are aerosol-generating procedures that potentially increase the risk of COVID-19 transmission. HIV testing in COVID-19 patients was also should be considered as part of directed screening in patients presenting with features of PJP, especially for those with unknown HIV status. The determination of an appropriate corticosteroid dose is important to treat both COVID-19 and PJP with severe clinical features. Proper diagnosis and treatment co-infections are urgently needed in this current pandemic to reduce morbidity and mortality.

摘要

由严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)引起的 2019 冠状病毒病(COVID-19)改变了医疗保健的重点,并成为全球公共卫生挑战。SARS-CoV-2 与包括真菌在内的其他微生物合并感染可导致诊断困难和预后更差。肺孢子菌肺炎(PJP)是人类免疫缺陷病毒(HIV)患者常见的机会性感染。然而,有时在胸部 X 光发现 PJP 后诊断延迟。我们报告一名患有 COVID-19 和 PJP 的 24 岁男性。逆转录聚合酶链反应显示 SARS-CoV-2 呈阳性。在胸部 X 光检查发现 PJP 后,HIV 诊断延迟。HIV 血清学呈阳性,绝对 CD4+细胞计数为 16 个/立方毫米。他接受了静脉注射瑞德西韦、静脉注射甲泼尼龙、肝素和静脉注射头孢哌酮-舒巴坦治疗。入院 25 天后出院。在门诊开始进行 HIV 治疗。对于并发 COVID-19 和 PJP 肺炎的放射学诊断很重要,特别是在无法进行痰或支气管肺泡灌洗(BAL)液显微镜检查的情况下,或者因为 BAL 和诱导痰是产生气溶胶的操作,可能会增加 COVID-19 传播的风险。对于出现 PJP 特征的 COVID-19 患者,HIV 检测也应被视为定向筛查的一部分,特别是对于那些 HIV 状态未知的患者。确定合适的皮质类固醇剂量对于治疗具有严重临床特征的 COVID-19 和 PJP 很重要。在当前这场大流行中,迫切需要正确诊断和治疗合并感染,以降低发病率和死亡率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd14/8493493/68c3a70819ec/gr1.jpg

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