School of Public Health, The University of Hong Kong, Hong Kong, China.
Department of Environmental Health Sciences, Columbia University, New York, NY 10027, USA.
Int J Environ Res Public Health. 2020 Aug 27;17(17):6210. doi: 10.3390/ijerph17176210.
Knowledge gaps remain regarding the cardiorespiratory impacts of ambient volatile organic compounds (VOCs) for the general population. This study identified contributing sources to ambient VOCs and estimated the short-term effects of VOC apportioned sources on daily emergency hospital admissions for cardiorespiratory diseases in Hong Kong from 2011 to 2014. We estimated VOC source contributions using fourteen organic chemicals by positive matrix factorization. Then, we examined the associations between the short-term exposure to VOC apportioned sources and emergency hospital admissions for cause-specific cardiorespiratory diseases using generalized additive models with polynomial distributed lag models while controlling for meteorological and co-pollutant confounders. We identified six VOC sources: gasoline emissions, liquefied petroleum gas (LPG) usage, aged VOCs, architectural paints, household products, and biogenic emissions. We found that increased emergency hospital admissions for chronic obstructive pulmonary disease were positively linked to ambient VOCs from gasoline emissions (excess risk (ER%): 2.1%; 95% CI: 0.9% to 3.4%), architectural paints (ER%: 1.5%; 95% CI: 0.2% to 2.9%), and household products (ER%: 1.5%; 95% CI: 0.2% to 2.8%), but negatively associated with biogenic VOCs (ER%: -6.6%; 95% CI: -10.4% to -2.5%). Increased congestive heart failure admissions were positively related to VOCs from architectural paints and household products in cold seasons. This study suggested that source-specific VOCs might trigger the exacerbation of cardiorespiratory diseases.
关于环境挥发性有机化合物 (VOCs) 对一般人群的心肺影响，知识仍存在空白。本研究确定了环境 VOCs 的贡献源，并估计了 2011 年至 2014 年香港 VOC 分配源对心肺疾病每日急诊入院的短期影响。我们使用正矩阵因子化法估算了 VOC 源的贡献。然后，我们使用广义加性模型和多项式分布滞后模型，在控制气象和共同污染物混杂因素的情况下，检查了短期暴露于 VOC 分配源与特定原因的心肺疾病急诊入院之间的关联。我们确定了六个 VOC 源：汽油排放、液化石油气 (LPG) 使用、老化 VOCs、建筑涂料、家用产品和生物排放。我们发现，慢性阻塞性肺病急诊入院增加与汽油排放 (超额风险 (ER%)：2.1%；95%置信区间：0.9%至 3.4%)、建筑涂料 (ER%：1.5%；95%置信区间：0.2%至 2.9%) 和家用产品 (ER%：1.5%；95%置信区间：0.2%至 2.8%) 中的环境 VOC 呈正相关，但与生物源 VOC 呈负相关 (ER%：-6.6%；95%置信区间：-10.4%至-2.5%)。充血性心力衰竭入院人数增加与寒冷季节建筑涂料和家用产品中的 VOC 呈正相关。本研究表明，特定源的 VOC 可能引发心肺疾病恶化。
