School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China.
Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA.
Environ Pollut. 2018 Nov;242(Pt B):1810-1816. doi: 10.1016/j.envpol.2018.07.086. Epub 2018 Jul 27.
Numerous epidemiological studies have indicated the adverse cardiovascular effects of air pollution on heart failure (HF) risk. However, little data are available directly evaluating the association of ambient volatile organic compounds (VOCs) with HF risk. We aimed to estimate the short-term effects of ambient VOCs on HF emergency hospitalizations in Hong Kong and to evaluate whether the associations were modified by sex and age.
We collected the daily VOCs concentrations from the Hong Kong Environmental Protection Department between April 2011 to December 2014. HF emergency hospital admission data were obtained from the Hospital Authority of Hong Kong. Generalized additive model (GAM) integrated with the distributed lag model (DLM) was used to estimate the excess risks of HF emergency hospitalizations with ambient concentrations of each VOCs groups - alkane, alkene, alkyne, benzene and substituted benzene.
We observed short-term effects of alkyne and benzene on an increased risk of HF emergency hospitalizations. The cumulative effect over 0-6 lag days (dlm) for an IQR increment of alkyne (1.17 ppb) was associated with 4.2% (95% CI: 1.18%-7.26%) increases of HF emergency hospitalizations, while the corresponding effect estimate over dlm for benzene per IQR (0.43 ppb) was 2.7% (95% CI: 0.39%-5.04%). Each VOCs groups was significantly associated with HF emergency hospitalizations in men.
Ambient volatile organic compounds, particularly alkyne and benzene, were associated with increased risks of heart failure in the Hong Kong population.
大量的流行病学研究表明，空气污染对心力衰竭（HF）风险存在不良心血管影响。然而，目前直接评估环境挥发性有机化合物（VOCs）与 HF 风险之间关联的数据有限。我们旨在评估香港环境 VOCs 浓度短期波动与 HF 急诊入院的关系，并评估这种关联是否受到性别和年龄的影响。
我们收集了香港环境保护署在 2011 年 4 月至 2014 年 12 月间的每日 VOCs 浓度数据。香港医院管理局提供了 HF 急诊入院数据。广义相加模型（GAM）结合分布滞后模型（DLM），用于估计每种 VOC 组（烷烃、烯烃、炔烃、苯和取代苯）的环境浓度与 HF 急诊入院之间的超额风险。
我们观察到炔烃和苯对 HF 急诊入院风险增加的短期影响。在 0-6 滞后天（dlm）内，炔烃（1.17 ppb）的 IQR 增量与 HF 急诊入院增加 4.2%（95%CI：1.18%-7.26%）相关，而苯在 dlm 内的相应效应估计值为 IQR（0.43 ppb）增加 2.7%（95%CI：0.39%-5.04%）。每个 VOC 组在男性中与 HF 急诊入院显著相关。
环境挥发性有机化合物，特别是炔烃和苯，与香港人群心力衰竭风险增加相关。
