Zhonghua Zhong Liu Za Zhi. 2020 Aug 23;42(8):617-623. doi: 10.3760/cma.j.cn112152-20200410-00330.
As a new type of anthracyclines, pegylated liposomal doxorubicin (PLD) is widely used in the treatment of a variety of malignant tumors, including soft tissue sarcoma, ovarian cancer, breast cancer, multiple myeloma, and so on. Compared with traditional anthracyclines, PLD can significantly decrease the incidences of adverse events such as cardiac toxicity and alopecia. However, the use of PLD will be accompanied with toxic side effects such as hand-foot syndrome, oral mucositis, and infusion reaction. This consensus will mainly focus on the mechanism, prevention and treatment of adverse events of PLD, in order to improve the therapeutic efficacy of PLD and life quality of patients.
聚乙二醇化脂质体阿霉素(PLD)作为一种新型蒽环类药物,广泛应用于多种恶性肿瘤的治疗,包括软组织肉瘤、卵巢癌、乳腺癌、多发性骨髓瘤等。与传统蒽环类药物相比,PLD可显著降低心脏毒性和脱发等不良事件的发生率。然而,PLD的使用会伴随手足综合征、口腔黏膜炎和输液反应等毒副作用。本共识将主要聚焦于PLD不良事件的机制、预防和治疗,以提高PLD的治疗效果和患者的生活质量。