Unit of Cognitive Neurology and Aphasia, Centro de Investigaciones Médico-Sanitarias (CIMES), University of Malaga, Málaga, Spain.
Research Laboratory on the Neuroscience of Language, Faculty of Psychology and Speech and Language Therapy, University of Malaga, Málaga, Spain.
Neuropsychol Rehabil. 2022 Jan;32(1):148-163. doi: 10.1080/09602011.2020.1809463. Epub 2020 Aug 31.
Depressive symptoms are a major drawback of aphasia, negatively impacting on functional outcomes. In a previous study, Intensive Language-Action Therapy (ILAT) was effective in improving depression and low mood in persons with chronic non-fluent aphasia. We present a proof-of-concept case-control study that evaluates language and mood outcomes amongst persons with fluent post-stroke aphasia. Thirteen Spanish speaking persons with fluent aphasia due to chronic stroke lesions in the left hemisphere participated in the study. Five participants (intervention group) received ILAT for 3 h/day during two consecutive weeks, for an overall of 30 h, and 8 participants (control group) entered a waiting-list no-treatment arm. The main finding was that participants receiving active treatment showed significant improvements on depression and aphasia severity scores, whereas no significant changes were found in the control group. The implementation of ILAT was efficient in improving clinical language deficits in people with fluent aphasia and contributes to improvement in mood after therapy.Trial registration: EUDRACT (2008-008481-12).
抑郁症状是失语症的一个主要缺陷，对功能结果产生负面影响。在之前的一项研究中，强化语言-动作疗法（ILAT）在改善慢性非流利性失语症患者的抑郁和情绪低落方面是有效的。我们提出了一项概念验证病例对照研究，评估了左半球慢性中风病变导致的流畅性中风后失语症患者的语言和情绪结果。13 名西班牙语流利性失语症患者参与了这项研究，他们的左半球有慢性中风病变。5 名参与者（干预组）接受了为期两周的每天 3 小时的强化语言-动作疗法治疗，总共 30 小时，8 名参与者（对照组）进入了无治疗等待名单。主要发现是，接受积极治疗的参与者在抑郁和失语症严重程度评分上有显著改善，而对照组则没有显著变化。ILAT 的实施在改善流畅性失语症患者的临床语言缺陷方面非常有效，并有助于治疗后情绪的改善。试验注册：EUDRACT（2008-008481-12）。
