Nephrology, Stollery Children's Hospital, Edmonton, Alberta, Canada.
Pediatrics, University of Alberta Faculty of Medicine and Dentistry, Edmonton, Alberta, Canada.
BMJ Open. 2020 Aug 30;10(8):e039342. doi: 10.1136/bmjopen-2020-039342.
Childhood obstructive sleep apnoea (OSA) is a highly prevalent disorder that may directly contribute to the development of obesity, hypertension and renal injury. Although those associations seem to be clearer in adults, studies in children have revealed conflicting results and updated synthesis of the evidence is lacking. The aim of this systematic review is to summarise the available evidence on the effect of OSA on obesity, systemic blood pressure and kidney function, to help to elucidate whether respiratory interventions to correct OSA would have the potential to improve those outcomes.
A systematic literature review search was created by a medical librarian and peer-reviewed by a second librarian prior to running. Ovid Medline, Ovid Embase, CINAHL via EbscoHOST, Wiley Cochrane Library and ProQuest Dissertations and Theses Global were searched on 25 February 2020. Titles and abstracts will be screened by two independent reviewers for inclusion, followed by full-text screening of relevant articles. Studies in children will be included if they report data on OSA and weight, systemic blood pressure or kidney parameters. The extracted data will be combined for analysis and the information subcategorised in groups based on outcome. Risk of bias will be determined using tools specific to study methodology and certainty of the evidence using the Grading of Recommendations, Assessment, Development and Evaluations approach.
This study will provide essential information for healthcare professionals to better understand the relationship between childhood OSA and changes in body mass index, systemic blood pressure and kidney function indicators. Our findings will be disseminated through conferences and publications. The results of this review may guide the initiation of new strategies and the development of future research studies. This research did not involve human subjects and therefore did not undergo research ethical review.
CRD42020171186.
儿童阻塞性睡眠呼吸暂停（OSA）是一种高发疾病，可能直接导致肥胖、高血压和肾脏损伤。尽管这些关联在成年人中似乎更为明显，但儿童研究的结果却存在冲突，并且缺乏对现有证据的更新综合。本系统评价的目的是总结有关 OSA 对肥胖、全身血压和肾功能影响的现有证据，以帮助阐明纠正 OSA 的呼吸干预是否有可能改善这些结果。
由一名医学图书馆员创建了系统文献检索，并在运行前由第二名图书馆员进行了同行评审。于 2020 年 2 月 25 日在 Ovid Medline、Ovid Embase、CINAHL 通过 EbscoHOST、Wiley Cochrane Library 和 ProQuest Dissertations and Theses Global 进行了检索。两名独立评审员将对标题和摘要进行筛选以纳入研究，然后对相关文章进行全文筛选。如果研究报告了 OSA 与体重、全身血压或肾脏参数的数据，则将其纳入儿童研究。提取的数据将进行合并分析，并根据结果对信息进行分组分类。使用特定于研究方法的工具来确定偏倚风险，并使用推荐评估、发展和评估方法（Grading of Recommendations, Assessment, Development and Evaluations approach）评估证据的确定性。
本研究将为医疗保健专业人员提供重要信息，以更好地理解儿童 OSA 与体重指数、全身血压和肾功能指标变化之间的关系。我们的研究结果将通过会议和出版物进行传播。本研究的结果可能为新策略的制定和未来研究的开展提供指导。本研究不涉及人类受试者，因此无需进行研究伦理审查。
CRD42020171186。
