阻塞性睡眠呼吸暂停治疗对肥胖儿童血脂的影响。
Effect of Obstructive Sleep Apnea Treatment on Lipids in Obese Children.
作者信息
Amini Zarlasht, Kotagal Suresh, Lohse Christine, Lloyd Robin, Sriram Swetha, Kumar Seema
机构信息
Department of Endocrinology, Children's Hospital of Eastern Ontario, Ottawa, ON K1H 8L1, Canada.
Division of Sleep Medicine; Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
出版信息
Children (Basel). 2017 Jun 1;4(6):44. doi: 10.3390/children4060044.
Obesity in children is associated with several co-morbidities including dyslipidemia. Obstructive sleep apnea (OSA) is commonly seen in obese children. In adults, diagnosis of OSA independent of obesity is associated with cardiometabolic risk factors including dyslipidemia. There is limited data on the impact of treatment of OSA on lipids in children. The objective of the study was to examine the impact of treatment of OSA on lipids in 24 obese children. Seventeen children were treated with continuous positive airway pressure (CPAP) and five underwent adenotonsillectomy. Mean apnea hypopnea index prior to treatment was 13.0 + 12.1 and mean body mass index (BMI) was 38.0 + 10.6 kg/m². Treatment of OSA was associated with improvement in total cholesterol (mean change = -11 mg/dL, < 0.001), and low-density lipoprotein cholesterol (mean change = -8.8 mg/dL, = 0.021). Obese children should be routinely screened for OSA, as treatment of OSA favorably influences lipids and therefore decreases their cardiovascular risk.
儿童肥胖与包括血脂异常在内的多种合并症相关。阻塞性睡眠呼吸暂停（OSA）在肥胖儿童中很常见。在成年人中，独立于肥胖的OSA诊断与包括血脂异常在内的心脏代谢危险因素相关。关于OSA治疗对儿童血脂影响的数据有限。该研究的目的是检查OSA治疗对24名肥胖儿童血脂的影响。17名儿童接受持续气道正压通气（CPAP）治疗，5名接受腺样体扁桃体切除术。治疗前平均呼吸暂停低通气指数为13.0 + 12.1，平均体重指数（BMI）为38.0 + 10.6 kg/m²。OSA治疗与总胆固醇改善相关（平均变化=-11 mg/dL，<0.001），以及低密度脂蛋白胆固醇改善相关（平均变化=-8.8 mg/dL，=0.021）。肥胖儿童应常规筛查OSA，因为OSA治疗对血脂有有利影响，因此可降低其心血管风险。
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