非酒精性脂肪性肝病与 COVID-19 严重程度相关，与代谢综合征无关：一项回顾性病例对照研究。

Nonalcoholic fatty liver disease is associated with COVID-19 severity independently of metabolic syndrome: a retrospective case-control study.

机构信息

Faculty of Medicine, Hebrew University of Jerusalem.

Department of gastroenterology and liver diseases, Shaare Zedek Medical Center, Jerusalem.

出版信息

Eur J Gastroenterol Hepatol. 2021 Dec 1;33(12):1578-1581. doi: 10.1097/MEG.0000000000001902.

DOI:10.1097/MEG.0000000000001902

PMID:32868652

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8555881/

Abstract

AIM

Coronavirus disease 2019 (COVID-19) is a recently encountered disease that was declared a pandemic by WHO in 2020. Obesity and other components of the metabolic syndrome may aggravate the severity of COVID-19. Nonalcoholic fatty liver disease (NAFLD) represents the hepatic manifestation of metabolic syndrome. The aim of this study was to investigate a possible association between MAFLD and COVID-19 severity.

METHODS

We performed a retrospective, case-control study, enrolling 71 consecutive COVID-19 patients who were divided into two groups according to the presence or absence of fatty liver by computed tomography scan. All medical records of eligible patients were reviewed including demographic, clinical, laboratory parameters and data regarding the presence of NAFLD and COVID-19 severity.

RESULTS

NAFLD was identified in 22/71 (31%) of the study group. Out of 71, thirteen suffered from severe COVID-19. NAFLD patients had more severe COVID-19 compared with non-NAFLD subjects, 8/22 (36.3%) vs. 5/49(10.2%), (P < 0.005), respectively. Multiple logistic regression analysis showed that NAFLD subjects were more likely to have severe COVID-19 disease (odds ratio 3.57, 95% confidence interval: 1.22, 14.48, P = 0.0031).

CONCLUSION

NAFLD represents a high risk for severe COVID-19 irrespective to gender, and independent of metabolic syndrome specifically in male gender. Moreover, obesity, hypertension and metabolic syndrome were also significantly associated with severe COVID-19.

摘要

目的

2019 年冠状病毒病（COVID-19）是一种新出现的疾病，世界卫生组织（WHO）于 2020 年宣布其为大流行。肥胖症和代谢综合征的其他成分可能会加重 COVID-19 的严重程度。非酒精性脂肪性肝病（NAFLD）是代谢综合征的肝脏表现。本研究旨在探讨 MAFLD 与 COVID-19 严重程度之间可能存在的关联。

方法

我们进行了一项回顾性病例对照研究，共纳入 71 例连续 COVID-19 患者，根据计算机断层扫描有无脂肪肝将其分为两组。回顾性分析所有符合条件患者的病历，包括人口统计学、临床、实验室参数以及 NAFLD 和 COVID-19 严重程度的数据。

结果

研究组中有 22/71（31%）患者存在 NAFLD。71 例患者中，有 13 例患有严重 COVID-19。与非 NAFLD 患者相比，NAFLD 患者的 COVID-19 更为严重，分别为 8/22（36.3%）和 5/49（10.2%）（P <0.005）。多因素逻辑回归分析显示，NAFLD 患者更有可能患有严重 COVID-19 疾病（比值比 3.57，95%置信区间：1.22，14.48，P = 0.0031）。