Department of Family Medicine, Wonkwang University Hospital, Sinyong-dong, 344-2, Iksan, Jeollabuk-do, Republic of Korea.
BMC Endocr Disord. 2021 May 1;21(1):91. doi: 10.1186/s12902-021-00758-x.
Although many studies on non-alcoholic fatty liver disease (NAFLD) are underway worldwide, and several existing studies have investigated the association between NAFLD and cardiovascular risk factors, studies comparing NAFLD and alcoholic fatty liver disease (AFLD) are scarce. This study aimed to evaluate differences between the incidence of cardiovascular risk factors and metabolic syndrome in NAFLD and AFLD.
A retrospective analysis of 913 patients who underwent abdominal computed tomography (CT) was performed to compare the incidence of cardiovascular risk factors and metabolic syndrome between NAFLD and AFLD. Subjects were divided into three groups based on criteria: healthy (n = 572), NAFLD (n = 295), and AFLD (n = 46). The healthy group had no liver disease. NAFLD was defined as fatty liver diagnosed on CT and drinking less than 140 g/week for men or 70 g/week for women. AFLD was defined as fatty liver diagnosed on CT and drinking more than 140 g/week for men or 70 g/week for women. We compared the incidence of cardiovascular risk factors and metabolic syndrome between the three groups. The relationship between each group and the metabolic syndrome risk was analyzed through multivariate logistic regression analysis.
No significant differences in several cardiovascular risk factors were observed between the NAFLD and AFLD groups. Upon analyzing the metabolic syndrome status in each group after making appropriate adjustments, the odds ratios (ORs) in the NAFLD (OR = 2.397, P = 0.002) and AFLD groups (OR = 4.445, P = 0.001) were found to be significantly higher than that in the healthy group; the incidence rate of metabolic syndrome was similar in the NAFLD and AFLD groups.
Both the NAFLD and AFLD groups had more cardiovascular risk factors and higher metabolic syndrome risk than the healthy group. Thus, the prevention of fatty liver disease, regardless of the specific type, should involve the identification of cardiovascular and metabolic syndrome risk factors. If abdominal CT reveals a fatty liver, whether NAFLD or AFLD, the risk of cardiovascular disease and metabolic syndrome should be assessed.
尽管全球范围内有许多关于非酒精性脂肪性肝病（NAFLD）的研究，并且已经有一些研究调查了 NAFLD 与心血管风险因素之间的关系，但比较 NAFLD 和酒精性脂肪性肝病（AFLD）的研究却很少。本研究旨在评估 NAFLD 和 AFLD 患者心血管风险因素和代谢综合征发生率的差异。
对 913 例行腹部计算机断层扫描（CT）的患者进行回顾性分析，比较 NAFLD 和 AFLD 患者心血管风险因素和代谢综合征的发生率。根据标准将受试者分为三组：健康组（n=572）、NAFLD 组（n=295）和 AFLD 组（n=46）。健康组无肝病。NAFLD 定义为 CT 诊断的脂肪肝，且男性每周饮酒量<140g 或女性每周饮酒量<70g。AFLD 定义为 CT 诊断的脂肪肝，且男性每周饮酒量>140g 或女性每周饮酒量>70g。我们比较了三组之间心血管风险因素和代谢综合征的发生率。通过多变量逻辑回归分析，分析了各组与代谢综合征风险的关系。
NAFLD 和 AFLD 组之间一些心血管风险因素无显著差异。在进行适当调整后，分析各组代谢综合征状况，发现 NAFLD 组（OR=2.397，P=0.002）和 AFLD 组（OR=4.445，P=0.001）的比值比（OR）显著高于健康组；NAFLD 组和 AFLD 组代谢综合征的发生率相似。
NAFLD 和 AFLD 组的心血管风险因素和代谢综合征风险均高于健康组。因此，无论特定类型如何，预防脂肪肝都应涉及识别心血管和代谢综合征的风险因素。如果腹部 CT 显示脂肪肝，无论是 NAFLD 还是 AFLD，都应评估心血管疾病和代谢综合征的风险。
