Augenstein W L, Kulig K W, Rumack B H
Rocky Mountain Poison and Drug Center, Denver, CO 80204.
JAMA. 1988 Jun 10;259(22):3302-5.
We present a case in which a patient took an overdose of captopril (Capoten) and alprazolam (Xanax) in a suicide attempt. The patient presented with hypotension (systolic blood pressure of 80 mm Hg) and drowsiness. The hypotension initially responded to administration of intravenous fluids and dopamine; however, it recurred twice at 18.5 and 24.5 hours after ingestion. These episodes again responded to administration of fluids and dopamine. A plasma captopril level of 27,391.1 nmol/L (5982 ng/mL) was documented, as well as a depressed level of angiotensin converting enzyme. Captopril is an angiotensin converting enzyme inhibitor used in the management of hypertension and ventricular failure; to our knowledge, this is the first case of an acute captopril overdose reported in the English-language literature. The role of captopril in inducing hypotension is discussed herein.
我们报告一例患者为自杀而过量服用卡托普利（开博通）和阿普唑仑（佳静安定）的病例。该患者出现低血压（收缩压80 mmHg）和嗜睡症状。低血压最初通过静脉补液和多巴胺治疗得到缓解；然而，在服药后18.5小时和24.5小时又复发了两次。这些发作再次通过补液和多巴胺治疗得到缓解。记录到血浆卡托普利水平为27391.1 nmol/L（5982 ng/mL），同时血管紧张素转换酶水平降低。卡托普利是一种用于治疗高血压和心力衰竭的血管紧张素转换酶抑制剂；据我们所知，这是英文文献中报道的首例急性卡托普利过量病例。本文讨论了卡托普利在诱发低血压中的作用。
