Department of Nephrology, 36673Cliniques Universitaires Saint-Luc, Institute of Experimental and Clinical Research, Université catholique de Louvain, Brussels, Belgium.
Division of Nephrology, Centre Hospitalier Universitaire Amiens-Picardie, Amiens, France.
Perit Dial Int. 2020 Sep;40(5):499-503. doi: 10.1177/0896860820953061. Epub 2020 Sep 1.
The pandemic of respiratory disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is life-threatening in peritoneal dialysis (PD) patients. In PD patients with systemic viral infections, peritoneal effluent may be theoretically contaminated. We searched for the presence of SARS-CoV-2 genetic material by real-time reverse transcriptase-polymerase chain reaction assays in serial PD effluents of three PD infected patients. Nasopharyngeal swabs obtained at admission showed high viral load in all three patients, whereas none of the PD effluent specimen tested positive, even after dialysate concentration. Those results support at most a very low SARS-CoV-2 dissemination risk by the peritoneal effluent of PD patients. Imposing special disposal procedures, such as the instillation of hypochlorite in the drainage bags to prevent viral spread to health-care workers, are probably not required.
由严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 引起的呼吸道疾病（COVID-19）大流行对腹膜透析（PD）患者具有生命威胁。在患有全身病毒感染的 PD 患者中，理论上腹膜灌流液可能受到污染。我们通过实时逆转录-聚合酶链反应检测，对 3 名 PD 感染患者的连续 PD 流出液中 SARS-CoV-2 遗传物质的存在情况进行了研究。3 名患者入院时的鼻咽拭子均显示病毒载量很高，而即使经过透析液浓缩，PD 流出液标本也均未检测到阳性结果。这些结果表明，PD 患者的腹膜灌流液中 SARS-CoV-2 的传播风险非常低。因此，可能不需要采取特殊处理程序，如向引流袋中注入次氯酸钠以防止病毒传播给医护人员。
