State Key Laboratory of Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China.
J Mater Chem B. 2020 Oct 14;8(38):8794-8802. doi: 10.1039/d0tb01687j. Epub 2020 Sep 1.
As the second leading cause of blindness in the world, glaucoma is mainly caused by persistent high intraocular pressure (IOP) that compresses the optic nerve and causes permanent damage. Noninvasive continuous monitoring of IOP is an essential method for the diagnosis and treatment of glaucoma. In this paper, we propose a new strain gauge material based on graphene nanowalls (GNWs) for continuous monitoring of IOP with high sensitivity in a wide range. By simulation, we studied the relationship between the strain of the cornea and contact lens and IOP. The structure and the location of the GNWs in the contact lens are optimized. A method for transferring GNWs on contact lenses with the assistance of a gold film is proposed. The simulated tests on porcine eyes in vitro show that the resistance response of the device to normal IOP fluctuation reaches 1.014 kΩ mmHg. Its normal sensitivity of 42 250 ppm mmHg and the response range of 0-75 mmHg are far more than those of most noninvasive methods reported before. This study shows the enormous potential of GNWs for continuous IOP monitoring with high sensitivity and low power consumption.
作为世界第二大致盲原因，青光眼主要是由持续的高眼内压（IOP）引起的，它会压迫视神经并导致永久性损伤。非侵入性的 IOP 连续监测是青光眼诊断和治疗的重要方法。在本文中，我们提出了一种基于石墨烯纳米墙（GNWs）的新型应变计材料，用于在宽范围内进行高灵敏度的 IOP 连续监测。通过模拟，我们研究了角膜和隐形眼镜的应变与 IOP 之间的关系。优化了隐形眼镜中 GNWs 的结构和位置。提出了一种在金膜辅助下将 GNWs 转移到隐形眼镜上的方法。体外猪眼的模拟测试表明，该设备对正常 IOP 波动的电阻响应达到 1.014 kΩ mmHg。其正常灵敏度为 42250 ppm mmHg，响应范围为 0-75 mmHg，远远超过之前报道的大多数非侵入性方法。这项研究表明，GNWs 在进行高灵敏度、低功耗的连续 IOP 监测方面具有巨大的潜力。
