Department of Urology, Qingpu Branch of Zhongshan Hospital affiliated to Fudan University, Shanghai, China.
School of Biological Science and Medical Engineering, Southeast University, Nanjing, China.
Adv Clin Exp Med. 2020 Aug;29(8):1001-1009. doi: 10.17219/acem/121521.
Previous studies have suggested that prostate-specific antigen (PSA) plays a role in the etiology of prostate cancer (PCa), and that polymorphisms of KLK3 may be associated with PCa. However, these results were conflicting. Therefore, we performed a meta-analysis to illuminate this problem. We searched the PubMed and Web of Science databases. Ten single nucleotide polymorphisms (SNPs) were involved in this meta-analysis. The pooled results showed that the minor alleles of rs1058205, rs2735839, rs174776, rs17632542, rs266849, rs266878, and rs2569735 were significantly associated with PCa. Compared to genotypes of the common homozygotes, the heterozygous genotypes of rs1058205, rs2735839, rs174776, rs17632542, rs266849, and rs266878 were significantly associated with PCa, as well as the homozygous genotypes of rs1058205, rs2735839, rs17632542, rs266878, rs266876, and rs2569735. Only rs2735839 was involved in the Gleason score (GS). The pooled results showed that when compared with GS ≥ 8 PCa, the A-allele was the protective factor for GS < 7 PCa. It was also a protective factor for GS ≥ 4+3 when compared to GS ≤ 3+4 PCa. A strong association was observed between PCa and rs1058205, rs2735839, rs266882, rs174776, rs17632542, rs266849, rs266878, rs266876, rs1058274, and rs2569735. The G-allele of rs2735839 was a risk factor for GS < 7 PCa when compared with the GS ≥ 8 PCa, as well as for the GS ≥ 4+3 when compared to the GS ≤ 3+4 PCa. Therefore, these SNPs may be valuable as biomarkers for PCa in the future.
先前的研究表明，前列腺特异性抗原（PSA）在前列腺癌（PCa）的病因学中起作用，KLK3 的多态性可能与 PCa 相关。然而，这些结果存在争议。因此，我们进行了一项荟萃分析来阐明这个问题。我们检索了 PubMed 和 Web of Science 数据库。该荟萃分析共涉及 10 个单核苷酸多态性（SNP）。汇总结果显示，rs1058205、rs2735839、rs174776、rs17632542、rs266849、rs266878 和 rs2569735 的次要等位基因与 PCa 显著相关。与常见纯合子的基因型相比，rs1058205、rs2735839、rs174776、rs17632542、rs266849 和 rs266878 的杂合基因型与 PCa 显著相关，而 rs1058205、rs2735839、rs17632542、rs266878、rs266876 和 rs2569735 的纯合基因型也是如此。只有 rs2735839 与 Gleason 评分（GS）有关。汇总结果显示，与 GS≥8 的 PCa 相比，A 等位基因是 GS<7 的 PCa 的保护因素。与 GS≤3+4 的 PCa 相比，它也是 GS≥4+3 的保护因素。PCa 与 rs1058205、rs2735839、rs266882、rs174776、rs17632542、rs266849、rs266878、rs266876、rs1058274 和 rs2569735 之间存在很强的关联。与 GS≥8 的 PCa 相比，rs2735839 的 G 等位基因是 GS<7 的 PCa 的危险因素，与 GS≤3+4 的 PCa 相比，它也是 GS≥4+3 的危险因素。因此，这些 SNP 将来可能成为 PCa 的有价值的生物标志物。
