三种激肽释放酶 3 基因变异与前列腺癌风险的关联。

Association between three genetic variants in kallikrein 3 and prostate cancer risk.

机构信息

Department of Urology, Huashan Hospital, Fudan University, 12 Central Urumqi Road, Shanghai 200040, China.

Department of Orthopedics, the Affiliated Jiangyin Hospital of Southeast University Medical School, Jiangyin 214400, China.

出版信息

Biosci Rep. 2018 Nov 30;38(6). doi: 10.1042/BSR20181151. Print 2018 Dec 21.

DOI:10.1042/BSR20181151

PMID:30413614

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6265624/

Abstract

BACKGROUND

Epidemiological studies have assessed the association between kallikrein 3 (KLK3) polymorphisms and prostate cancer (PCa) susceptibility. However, published data on this association are somewhat inconclusive.

METHODS

Articles investigating the association between three KLK3 (rs1058205, rs2735839, and rs266882) variants and PCa susceptibility were searched from online databases, which included 35,838 patients and 36,369 control participants. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to demonstrate the strength of the association. We also utilized ELISA to detect serum expression of KLK3. In addition, tools were adopted to evaluate the relationship of KLK3 expression and PCa survival time.

RESULTS

The overall results indicated that polymorphism T>C of rs1058205 was associated with decreased risk of PCa (allele contrast: OR = 0.75, 95% CI = 0.64-0.88, < 0.001; homozygote comparison: OR = 0.58, 95% CI = 0.42-0.81, < 0.001), particularly in Caucasian population (allele contrast: OR = 0.77, 95% CI = 0.65-0.91, < 0.001; homozygote comparison: OR = 0.58, 95% CI = 0.41-0.82, < 0.001). No association was observed between the polymorphism A>G of rs2735839 and risk of PCa. In addition, no association was observed between polymorphism A>G of rs266882 and risk of PCa. Serum KLK3 levels in PCa patients carrying CC/CT genotypes were statistically lower than those carrying TT genotypes. Conclusion This meta-analysis suggests that rs1058205 polymorphism of KLK3 is a risk factor for PCa development, polymorphism T>C of rs1058205 is associated with decreased susceptibility to PCa particularly in Caucasian population.

摘要

背景

流行病学研究评估了激肽释放酶 3（KLK3）多态性与前列腺癌（PCa）易感性之间的关系。然而，关于这种相关性的已发表数据有些不一致。

方法

从在线数据库中搜索了三篇关于 KLK3（rs1058205、rs2735839 和 rs266882）变体与 PCa 易感性之间的关联的文章，其中包括 35838 名患者和 36369 名对照参与者。比值比（OR）和 95%置信区间（CI）用于表示关联的强度。我们还利用 ELISA 检测 KLK3 的血清表达。此外，采用工具来评估 KLK3 表达与 PCa 生存时间的关系。

结果

总体结果表明，rs1058205 的 T>C 多态性与 PCa 风险降低相关（等位基因对比：OR=0.75，95%CI=0.64-0.88，<0.001；纯合子比较：OR=0.58，95%CI=0.42-0.81，<0.001），尤其是在白种人群中（等位基因对比：OR=0.77，95%CI=0.65-0.91，<0.001；纯合子比较：OR=0.58，95%CI=0.41-0.82，<0.001）。rs2735839 的 A>G 多态性与 PCa 风险之间没有关联。此外，rs266882 的 A>G 多态性与 PCa 风险之间也没有关联。携带 CC/CT 基因型的 PCa 患者的血清 KLK3 水平明显低于携带 TT 基因型的患者。结论：本荟萃分析表明，KLK3 的 rs1058205 多态性是 PCa 发展的危险因素，rs1058205 的 T>C 多态性与 PCa 易感性降低有关，特别是在白种人群中。