School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China.
The Modernization Engineering Technology Research Center of Ethnic Minority Medicine of Hubei Province, School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China.
J Nat Prod. 2020 Sep 25;83(9):2756-2763. doi: 10.1021/acs.jnatprod.0c00695. Epub 2020 Sep 1.
Seven new merosesquiterpenoids, trichothecrotocins D-J (-), two new trichothecene sesquiterpenoids, trichothecrotocins K () and L (), and six known compounds (-, , and ), were isolated from a potato-associated fungus, . Compounds and were racemates which were further separated as pure enantiomers. Structures together with absolute configurations were established by extensive spectroscopic analysis, as well as quantum chemistry calculations on ECD and optical rotations. Compounds - are rare meroterpenoids featuring a -phenyl group, while and possessed a novel 6-6/5 fused ring system. Compounds -, , , and showed antifungal activity against four plant pathogens with MIC values of 8-128 μg/mL. It is suggested that the meroterpenoids produced by may play an important role in the antifungal property of the fungus, thereby protecting the host plant, i.e., potato.
从与土豆有关的真菌 Trichoderma longibrachiatum 中分离得到了 7 个新的倍半萜类化合物，即 trichothecrotocins D-J (-)，2 个新的曲古抑菌素倍半萜类化合物，trichothecrotocins K () 和 L ( )，以及 6 个已知化合物 (-,, 和 )。化合物和是外消旋体，进一步分离为纯对映异构体。通过广泛的光谱分析以及 ECD 和旋光的量子化学计算，确定了结构和绝对构型。化合物 - 是罕见的具有 -苯基的倍半萜类化合物，而和具有新颖的 6-6/5 稠合环系统。化合物 -,,, 和 对 4 种植物病原菌具有抗真菌活性，MIC 值为 8-128 μg/mL。这表明由产生的倍半萜类化合物可能在真菌的抗真菌特性中发挥重要作用，从而保护宿主植物，即土豆。
