Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Research and Development Center for Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, P. R. China.
Yunnan Institute of Microbiology, Yunnan University, Kunming, 650091, P. R. China.
Chem Biodivers. 2021 Mar;18(3):e2000964. doi: 10.1002/cbdv.202000964. Epub 2021 Feb 4.
Endophytic fungi play important roles for host's stress tolerance including invasion by pathogenic microbes. Small molecules are common weapons in the microbe-microbe interactions. Panax notoginseng is a widely used traditional Chinese medicinal plant and harbors many endophytes, some exert functions against pathogens. Here, we report six new compounds named myrothins A-F (1-6) produced by Myrothecium sp. BS-31, an endophyte isolated from P. notoginseng, and their antifungal activities against pathogenic fungi causing host root-rot disease. Their structures were elucidated with analysis of spectroscopic data including 1D and 2D NMR, HR-ESI-MS. Myrothins B (2) and E (5) showed the weak activity against Fusarium oxysporum and Phoma herbarum, and myrothins F (6) showed weak activity against F. oxysporum.
内生真菌在宿主的胁迫耐受中发挥着重要作用，包括抵御病原微生物的入侵。小分子是微生物-微生物相互作用中的常见武器。三七是一种广泛使用的传统中药植物，含有许多内生菌，其中一些具有抗病原体的功能。在这里，我们报道了六种新的化合物，命名为 myrothins A-F（1-6），由内生真菌 Myrothecium sp. BS-31 产生，该内生真菌分离自三七，它们具有抗引起宿主根腐病的病原真菌的活性。通过分析包括 1D 和 2D NMR、HR-ESI-MS 在内的光谱数据，阐明了它们的结构。Myrothins B（2）和 E（5）对尖孢镰刀菌和叶点霉表现出较弱的活性，而 Myrothins F（6）对尖孢镰刀菌表现出较弱的活性。
