Taussig S J, Batkin S
Department of Food Science and Human Nutrition, School of Tropical Agriculture, University of Hawaii, Honolulu.
J Ethnopharmacol. 1988 Feb-Mar;22(2):191-203. doi: 10.1016/0378-8741(88)90127-4.
After a short description of the uses of pineapple as folk medicine by the natives of the tropics, the more important new pharmaceutical applications of bromelain, reported between 1975 and 1978, are presented. Although the exact chemical structure of all active components of bromelain is not fully determined, this substance has shown distinct pharmacological promise. Its properties include: (1) interference with growth of malignant cells; (2) inhibition of platelet aggregation; (3) fibrinolytic activity; (4) anti-inflammatory action; (5) skin debridement properties. These biological functions of bromelain, a non-toxic compound, have therapeutic values in modulating: (a) tumor growth; (b) blood coagulation; (c) inflammatory changes; (d) debridement of third degree burns; (e) enhancement of absorption of drugs. The mechanism of action of bromelain affecting these varied biological effects relates in part to its modulation of the arachidonate cascade.
在简要描述了热带地区当地人将菠萝用作民间药物的用途之后，本文介绍了1975年至1978年间报道的菠萝蛋白酶更重要的新药物应用。尽管菠萝蛋白酶所有活性成分的确切化学结构尚未完全确定，但这种物质已显示出明显的药理学前景。其特性包括：（1）干扰恶性细胞生长；（2）抑制血小板聚集；（3）纤维蛋白溶解活性；（4）抗炎作用；（5）皮肤清创特性。菠萝蛋白酶这种无毒化合物的这些生物学功能在调节以下方面具有治疗价值：（a）肿瘤生长；（b）血液凝固；（c）炎症变化；（d）三度烧伤的清创；（e）增强药物吸收。菠萝蛋白酶影响这些不同生物学效应的作用机制部分与其对花生四烯酸级联反应的调节有关。
