Ma Chao, Li Haoyu, Lu Shuwen, Li Xian, Wang Shuai, Wang Wenzhan
Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
Department of Ophthalmology, the Second Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.
J Inflamm Res. 2023 Mar 2;16:927-939. doi: 10.2147/JIR.S402900. eCollection 2023.
Ocular injuries caused by inflammation, surgery or accidents are subject to a physiological healing process that ultimately restores the structure and function of the damaged tissue. Tryptase and trypsin are essential component of this process and they play a role in promoting and reducing the inflammatory response of tissues, respectively. Following injury, tryptase is endogenously produced by mast cells and can exacerbate the inflammatory response both by stimulating neutrophil secretion, and through its agonist action on proteinase-activated receptor 2 (PAR2). In contrast, exogenously introduced trypsin promotes wound healing by attenuating inflammatory responses, reducing oedema and protecting against infection. Thus, trypsin may help resolve ocular inflammatory symptoms and promote faster recovery from acute tissue injury associated with ophthalmic diseases. This article describes the roles of tryptase and exogenous trypsin in affected tissues after onset of ocular injury, and the clinical applications of trypsin injection.
由炎症、手术或事故引起的眼部损伤会经历一个生理愈合过程，最终恢复受损组织的结构和功能。类胰蛋白酶和胰蛋白酶是这一过程的重要组成部分，它们分别在促进和减轻组织的炎症反应中发挥作用。受伤后，类胰蛋白酶由肥大细胞内源性产生，它可通过刺激中性粒细胞分泌以及对蛋白酶激活受体2（PAR2）的激动作用来加剧炎症反应。相比之下，外源性引入的胰蛋白酶通过减轻炎症反应、减轻水肿和预防感染来促进伤口愈合。因此，胰蛋白酶可能有助于缓解眼部炎症症状，并促进与眼科疾病相关的急性组织损伤更快恢复。本文描述了眼部损伤发生后类胰蛋白酶和外源性胰蛋白酶在受影响组织中的作用，以及胰蛋白酶注射的临床应用。
