基于 DNA 哑铃型结构的可逆 Mg/EDTA 控制的分子开关的合理设计。
Rational design of a reversible Mg/EDTA-controlled molecular switch based on a DNA minidumbbell.
机构信息
Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.
School of Biology and Biological Engineering, South China University of Technology, Guangzhou, Guangdong 510006, China.
出版信息
Chem Commun (Camb). 2020 Sep 1;56(70):10127-10130. doi: 10.1039/d0cc03774e.
Here we report that incorporation of an abasic site to DNA minidumbbells formed by natural sequences can lead to significant enhancements in their thermodynamic stability. Based on these stable minidumbbells, the first metal ion-controlled molecular switch which can regulate instant and reversible DNA duplex formation and dissociation has been constructed.
在这里，我们报告称，在由天然序列形成的 DNA 哑铃型结构中引入无碱基位点可以显著提高其热力学稳定性。基于这些稳定的哑铃型结构，我们构建了第一个可以调控瞬间和可逆 DNA 双链体形成和解离的金属离子控制的分子开关。
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