临床试验：参与知识和态度的预测因素。
Clinical trials: Predictors of knowledge and attitudes towards participation.
机构信息
Department of Clinical Pharmacy and Biopharmaceutics, School of Pharmacy, University of Jordan, Amman, Jordan.
Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
出版信息
Int J Clin Pract. 2021 Mar;75(3):e13687. doi: 10.1111/ijcp.13687. Epub 2020 Sep 21.
AIMS
Clinical trials (CTs) are critical to advancing of patient care. Understanding the public's knowledge and the attitudes towards participating in CTs is important for their successful implication. In Jordan this data are currently not available. The present study aimed to explore the knowledge, attitude and perception of Jordanians towards CTs participation.
METHODS
A cross-sectional study was conducted on 1216 Jordanians recruited from public hospitals and pharmaceutical research centres.
RESULTS
About 20.5% of the respondents have previously participated in a CT. About 68.3% and 50.1% had good knowledge and positive attitude towards CTs, respectively. Good knowledge was associated with male gender (OR = 1.696, 95% CI = 1.284-0.240, P < .001), higher education (OR = 1.433, 95% CI = 1.107-1.856, P = .006) and healthy condition (OR = 1.822, 95% CI = 1.234-2.690, P = .003); while older age was associated with a poor knowledge (OR = 0.985, 95% CI = 0.972-0.998, P = .026). Female gender (OR = 1.817, 95% CI = 1.406-2.349, P < .001), higher education (OR = 1.294, 95% CI = 1.017-1.646, P = .036) and previous participation (OR = 1.919, 95% CI = 1.388-2.653, P < .001) were factors predicting the positive attitudes. A very weak positive correlation was found between knowledge and attitude (Spearman's r = 0.074, P = .01). Regarding perceptions, most of the respondents (85.3%) perceive that CTs are conducted in an ethical manner in Jordan, only 52.9% however feel comfortable towards participation. A moderate positive correlation was found between knowledge and perception (Spearman's r = 0.275, P < .001). Taking part in a CT significantly affect knowledge, attitudes and perceptions.
CONCLUSIONS
This study revealed important insights regarding knowledge, attitudes and perception of Jordanians towards CTs. Educational interventions can improve awareness of the ethical standards under which CTs are conducted affecting the perception to participate. Promotion of CTs among patients and healthy individuals is needed to increase participation.
目的
临床试验（CTs）对于推进患者护理至关重要。了解公众对参与 CTs 的知识和态度对于其成功实施至关重要。目前，约旦没有关于这方面的数据。本研究旨在探讨约旦人对参与 CTs 的知识、态度和看法。
方法
本研究采用横断面研究，在 1216 名从公立医院和制药研究中心招募的约旦人中进行。
结果
约 20.5%的受访者之前参加过 CT。约 68.3%和 50.1%的人对 CTs 有较好的了解和积极的态度，分别。良好的知识与男性性别（比值比 [OR] = 1.696，95%置信区间 [CI] = 1.284-0.240，P <.001）、较高的教育水平（OR = 1.433，95%CI = 1.107-1.856，P = 0.006）和健康状况（OR = 1.822，95%CI = 1.234-2.690，P = 0.003）有关；而年龄较大与知识较差有关（OR = 0.985，95%CI = 0.972-0.998，P = 0.026）。女性性别（OR = 1.817，95%CI = 1.406-2.349，P <.001）、较高的教育水平（OR = 1.294，95%CI = 1.017-1.646，P = 0.036）和以前的参与（OR = 1.919，95%CI = 1.388-2.653，P <.001）是预测积极态度的因素。知识和态度之间存在微弱的正相关（Spearman's r = 0.074，P = 0.01）。关于看法，大多数受访者（85.3%）认为 CT 在约旦是按照伦理标准进行的，只有 52.9%的人对参与感到舒适。知识和看法之间存在中度正相关（Spearman's r = 0.275，P <.001）。参与 CT 显著影响知识、态度和看法。
结论
本研究揭示了约旦人对 CTs 的知识、态度和看法的重要见解。教育干预可以提高对 CT 实施所依据的伦理标准的认识，从而影响参与的看法。需要在患者和健康人群中推广 CT 以增加参与率。
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