Suvorov A N, Golubkov V I, Tomolian A T
Mol Gen Mikrobiol Virusol. 1988 Feb(2):3-12.
The data on the cloning of the main pathogenic determinants of group A streptococci including M-protein, erythrogenic toxin, streptokinase, streptolysin O are analyzed. The scientific importance and the possible ways to use the data obtained after cloning are discussed. The hypothesis on the operon system of a number of streptococcal virulence factors regulation is discussed. Construction of vector systems for streptococcal genes cloning is summarized.
分析了关于A组链球菌主要致病决定因素克隆的数据，包括M蛋白、致热外毒素、链激酶、链球菌溶血素O。讨论了克隆后所获数据的科学重要性及可能的应用方式。探讨了一些链球菌毒力因子调控的操纵子系统假说。总结了用于链球菌基因克隆的载体系统构建。
