生长激素和基因多态性是否影响垂体腺瘤的发生和表现？
Do and Gene Polymorphisms Impact the Development and Manifestation of Pituitary Adenoma?
机构信息
Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
Neuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
出版信息
In Vivo. 2020 Sep-Oct;34(5):2499-2505. doi: 10.21873/invivo.12066.
BACKGROUND/AIM: To evaluate the association between TRIB1(rs6987702) and IL-9(rs1859430, rs2069870) genotypes with the development and manifestation of pituitary adenoma (PA).
MATERIALS AND METHODS
The study group included 141 patients with PA and the control group consisted of 287 healthy people. The genotyping of rs6987702, rs1859430 and rs2069870 was carried out using a real-time polymerase chain reaction.
RESULTS
Statistically significant results were obtained regarding the rs1859430, but there were no significant results regarding rs6987702. We found that the rs1859430 A/A genotype increased the odds of having recurrent PA six times (p=0.006) under the co-dominant model and four times (p=0.021) under the recessive model. Furthermore, the analysis showed that the G/A genotype increased the odds of having recurrent PA 2.3 times (p=0.003) under the co-dominant model, while G/A and A/A genotypes increased the odds 2.7 times (p=0.011) under the over-dominant model.
CONCLUSION
Certain genotypes of rs1859430 can be associated with PA recurrence.
背景/目的：评估 TRIB1(rs6987702) 和 IL-9(rs1859430、rs2069870) 基因型与垂体腺瘤 (PA) 的发生和表现之间的关联。
材料和方法
研究组包括 141 例 PA 患者，对照组包括 287 名健康人。使用实时聚合酶链反应对 rs6987702、rs1859430 和 rs2069870 进行基因分型。
结果
rs1859430 存在统计学显著结果，但 rs6987702 无显著结果。我们发现，在共显性模型下，rs1859430 A/A 基因型使复发性 PA 的发生几率增加了六倍 (p=0.006)，在隐性模型下增加了四倍 (p=0.021)。此外，分析表明，在共显性模型下，rs1859430 G/A 基因型使复发性 PA 的发生几率增加了 2.3 倍 (p=0.003)，而 G/A 和 A/A 基因型使复发性 PA 的发生几率增加了 2.7 倍 (p=0.011)在超显性模型下。
结论
某些 rs1859430 基因型可能与 PA 复发有关。
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