Zhao Jian, Zhu Xiang-Yu, Ren Yan, Li Jin-Yuan
Kailuan General Hospital, Tangshan.
School of stomatology, North China University of Science and Technology, Hebei China.
Medicine (Baltimore). 2020 Aug 14;99(33):e21566. doi: 10.1097/MD.0000000000021566.
Metabolic syndrome (MetS) refers to the pathological state of metabolic disorders in the body's proteins, fats, carbohydrates and other substances. MetS is a systemic metabolic disease. Periodontal disease is also a part of systemic inflammatory diseases. Among Chinese patients with middle-aged and elderly MetS, the periodontal morbidity is very high, which is due to the involvement of inflammatory mediators in the pathogenesis of MetS and periodontal disease. The latter may also be a risk factor for the former's morbidity and promotion of disease progression. At present, there are not many investigations and studies on periodontal examination data and periodontal disease prevalence of patients with MetS. Coal mine workers, especially coal mine underground workers, have different work natures and different working environments. See related report.We will collect the clinical diagnosis and treatment information of the enrolled patients. We will focus on checking the incidence of periodontal disease and recording. Establish a database, check every 10 medical records, and make corrections in time to ensure data accuracy. We will popularize oral hygiene knowledge for the included patients and guide them to brush their teeth correctly and how to use dental floss. We will perform periodontal examination on the patients' teeth by site and record the plaque index, gingival sulcus bleeding index, periodontal pocket exploration depth and other indicators. We will repeat the above inspection items and record in the second and fourth weeks of the experiment.This study will explore the correlation between periodontal disease and MetS of coal mine workers. We aim to clarify the role and mechanism of MetS in the occurrence and development of periodontal diseases, guide the prevention of periodontal diseases, and thus reduce the prevalence of periodontal diseases. TRIAL REGISTRATION:: ClinicalTrials.gov, ChiCTR2000034177, Registered on 27 June 2020.
代谢综合征（MetS）是指机体蛋白质、脂肪、碳水化合物等物质代谢紊乱的病理状态。代谢综合征是一种全身性代谢疾病。牙周病也是全身性炎症性疾病的一部分。在我国中老年代谢综合征患者中，牙周病发病率很高，这是由于炎症介质参与了代谢综合征和牙周病的发病机制。后者也可能是前者发病及疾病进展的危险因素。目前，关于代谢综合征患者牙周检查数据及牙周病患病率的调查研究较少。煤矿工人，尤其是煤矿井下工人，工作性质不同，工作环境也不同。见相关报道。我们将收集入选患者的临床诊疗信息。重点检查牙周病发病率并进行记录。建立数据库，每检查10份病历就进行核对，及时纠错以确保数据准确性。我们将为纳入研究的患者普及口腔卫生知识，指导他们正确刷牙以及如何使用牙线。我们将对患者牙齿进行逐部位牙周检查，并记录菌斑指数、牙龈沟出血指数、牙周袋探诊深度等指标。在实验的第二周和第四周重复上述检查项目并记录。本研究将探讨煤矿工人牙周病与代谢综合征之间的相关性。我们旨在阐明代谢综合征在牙周病发生发展中的作用及机制，指导牙周病的预防，从而降低牙周病的患病率。试验注册：ClinicalTrials.gov，ChiCTR2000034177，于2020年6月27日注册。
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