Qi Qibin, Yu Zhijie, Ye Xingwang, Zhao Feng, Huang Ping, Hu Frank B, Franco Oscar H, Wang Jing, Li Huaixing, Liu Yong, Lin Xu
Key Laboratory of Systems Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China.
J Clin Endocrinol Metab. 2007 Dec;92(12):4827-34. doi: 10.1210/jc.2007-1219. Epub 2007 Sep 18.
High retinol-binding protein 4 (RBP4) is thought to be associated with insulin resistance in humans. However, evidence from large-scale populations about the relationship between RBP4 and metabolic diseases is scarce.
We evaluated plasma RBP4 distribution and its association with metabolic syndrome (MetS) among middle-aged and older Chinese.
We evaluated plasma RBP4 in a cross-sectional sample of 3289 Chinese aged from 50 to 70 yr in Beijing and Shanghai by using an in-house developed and validated sandwich ELISA. MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian-Americans.
RBP4 levels were higher in male and Beijing residents, compared with female and Shanghai participants (both P < 0.001). RBP4 levels were associated positively with body mass index, waist circumference, triglycerides, total and low-density lipoprotein cholesterol, blood pressure, fasting insulin, and homeostatic model assessment of insulin resistance and negatively with high-density lipoprotein cholesterol and adiponectin (all P < 0.001). In the highest RBP4 quartile, the MetS risk was significantly higher (odds ratio 2.58; 95% confidence interval 2.08-3.20) than in the lowest quartile after adjustment for potential confounders. This association remained strong (odds ratio 2.25; 95% confidence interval 1.72-2.94) after further controlling for C-reactive protein, adiponectin, homeostatic model assessment of insulin resistance, and body mass index.
This first large-scale population study shows that elevated RBP4 levels are strongly and independently associated with MetS. Prospective studies are needed to establish the role of RBP4 in the development of MetS and related diseases.
高视黄醇结合蛋白4（RBP4）被认为与人类胰岛素抵抗有关。然而，来自大规模人群的关于RBP4与代谢性疾病之间关系的证据很少。
我们评估了中国中老年人群血浆RBP4分布及其与代谢综合征（MetS）的关联。
我们使用自行开发并验证的夹心酶联免疫吸附测定法（ELISA），对来自北京和上海的3289名年龄在50至70岁的中国横断面样本中的血浆RBP4进行了评估。MetS根据更新后的美国国家胆固醇教育计划成人治疗小组III针对亚裔美国人的标准进行定义。
与女性和上海参与者相比，男性和北京居民的RBP4水平更高（均P<0.001）。RBP4水平与体重指数、腰围、甘油三酯、总胆固醇和低密度脂蛋白胆固醇、血压、空腹胰岛素以及胰岛素抵抗的稳态模型评估呈正相关，与高密度脂蛋白胆固醇和脂联素呈负相关（均P<0.001）。在最高RBP4四分位数组中，在调整潜在混杂因素后，MetS风险显著高于最低四分位数组（比值比2.58；95%置信区间2.08 - 3.20）。在进一步控制C反应蛋白、脂联素、胰岛素抵抗的稳态模型评估和体重指数后，这种关联仍然很强（比值比2.25；95%置信区间1.72 - 2.94）。
这项首次大规模人群研究表明，RBP4水平升高与MetS密切且独立相关。需要进行前瞻性研究以确定RBP4在MetS及相关疾病发生发展中的作用。
