灵芝孢子粉对痴呆后癫痫海马组织中钙敏感受体及凋亡相关蛋白的影响：一项系统评价方案
Effects of spore powder of ganoderma lucidum on CaSR and apoptosis-related proteins in hippocampus tissue of epilepsy following dementia: A protocol of systematic review.
作者信息
Qin Li-Hong, Wang Chen, Jiang Xiao-Xue, Song You, Feng Yao, Qin Li-Wei, Zhang Shu-Ping
机构信息
First Ward of Neurology Department.
Second Ward of Neurology Department.
出版信息
Medicine (Baltimore). 2020 Aug 14;99(33):e21711. doi: 10.1097/MD.0000000000021711.
BACKGROUND
This study will investigate the effects of Spore Powder of Ganoderma Lucidum (SPGL) on CaSR and apoptosis-related proteins (ARP) in hippocampus tissue of epilepsy following dementia.
METHODS
This study will retrieve all potential studies from both electronic databases (Cochrane Library, EMBASE, MEDLINE, CINAHL, AMED, and CNKI) and other literature sources to assess the effects of SPGL on CaSR and ARP in hippocampus tissue of epilepsy following dementia. We will search all literature sources from the inception to the present. All eligible case-control studies will be included in this study. Two authors will independently carry out literature selection, data collection, and study quality evaluation. Any divergence will be resolved by another author through discussion. RevMan 5.3 software will be employed for data analysis.
RESULTS
This study will summarize existing evidence to assess the effects of SPGL on CaSR and ARP in hippocampus tissue of epilepsy following dementia.
CONCLUSIONS
The findings of this study may provide helpful evidence of SPGL on CaSR and ARP in hippocampus tissue of epilepsy following dementia.
SYSTEMATIC REVIEW REGISTRATION
INPLASY202070041.
背景
本研究将探讨灵芝孢子粉（SPGL）对痴呆后癫痫海马组织中钙敏感受体（CaSR）和凋亡相关蛋白（ARP）的影响。
方法
本研究将从电子数据库（Cochrane图书馆、EMBASE、MEDLINE、CINAHL、AMED和中国知网）以及其他文献来源检索所有潜在研究，以评估SPGL对痴呆后癫痫海马组织中CaSR和ARP的影响。我们将检索从起始到目前的所有文献来源。所有符合条件的病例对照研究都将纳入本研究。两位作者将独立进行文献筛选、数据收集和研究质量评估。任何分歧将由另一位作者通过讨论解决。将使用RevMan 5.3软件进行数据分析。
结果
本研究将总结现有证据，以评估SPGL对痴呆后癫痫海马组织中CaSR和ARP的影响。
结论
本研究结果可能为SPGL对痴呆后癫痫海马组织中CaSR和ARP的影响提供有用证据。
系统评价注册
INPLASY202070041。
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