Lin XiaoGuang, Zhang XueLing, Liu QinQin, Zhao PanWen, Zhong JianGuo, Pan PingLei, Wang GenDi, Yi ZhongQuan
Department of Neurology, Affiliated Suqian Hospital of Xuzhou Medical University, Suqian.
Department of Central Laboratory.
Medicine (Baltimore). 2020 Aug 14;99(33):e21773. doi: 10.1097/MD.0000000000021773.
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS). Recently, numerous studies have shown that MS disrupts a number of social cognitive abilities, including empathy, theory of mind (ToM), and facial emotion recognition. In contrast to well-documented deficits in the core social cognitive domains of ToM and facial emotion recognition, it is not clear the broad and specific subcomponents of empathy processing affected. In addition, the specific subcomponents of ToM affected in MS are also unclear. The aim of this study is to conduct a systematic review and meta-analysis to characterize the performance of empathy and ToM in MS.
A systematic literature search will be performed for eligible studies published up to July 1st, 2020 in 3 international databases (PubMed, Web of Science, and Embase). The work such as article retrieval, screen, quality evaluation, data collection will be conducted by 2 independent researchers. Meta-analysis will be performed using Stata 15.0 software.
The results of this study will be published in a peer-reviewed journal.
This meta-analysis will provide a high-quality synthesis from existing evidence for the performance of empathy and ToM in MS.
INPLASY202070029.
多发性硬化症（MS）是一种中枢神经系统（CNS）的免疫介导性脱髓鞘疾病。最近，大量研究表明，MS会破坏多种社会认知能力，包括同理心、心理理论（ToM）和面部表情识别。与心理理论和面部表情识别等核心社会认知领域中记录详尽的缺陷不同，目前尚不清楚同理心加工中受到影响的广泛和具体子成分。此外，MS中受影响的心理理论的具体子成分也不清楚。本研究的目的是进行系统评价和荟萃分析，以描述MS患者在同理心和心理理论方面的表现。
将对截至2020年7月1日在3个国际数据库（PubMed、科学网和Embase）上发表的符合条件的研究进行系统的文献检索。文章检索、筛选、质量评估、数据收集等工作将由2名独立研究人员进行。将使用Stata 15.0软件进行荟萃分析。
本研究结果将发表在同行评审期刊上。
这项荟萃分析将根据现有证据对MS患者在同理心和心理理论方面的表现进行高质量的综合分析。
PROSPERO注册号：INPLASY202070029。
