Fang Peng-Zhong, Chen Ya-Min, Chen Jin-Lei, Sun Jun-Hao, Tan Jian-Shi, Wang Rui-Rui, Wang Xin
The First Clinical Medical College of Lanzhou University, Lanzhou City.
Evidence-Based Nursing Center, School of Nursing, Lanzhou University.
Medicine (Baltimore). 2020 Aug 14;99(33):e21811. doi: 10.1097/MD.0000000000021811.
Osteoporosis is a disease with a high prevalence and low treatment rate, which poses a serious threat to the lives of patients and brings a heavy economic burden. Clinical practice guidelines (CPGs) provide vital guidance for disease management. Up to now, different countries, regions, and organizations have issued a certain number of CPGs for osteoporosis, but the recommendations in different guidelines are inconsistent. This protocol plans to evaluate the quality of the CPGs for osteoporosis and then make a comparative analysis of the recommendations in the CPGs.
Several databases including PubMed, Web of Science, Embase, and Cochrane Library, as well as the official website of relevant organizations will be searched. Screen and data extraction will be performed by two reviewers independently, and the third reviewer help to resolve the divergence between them. Using the AGREE II instrument and RIGHT checklist to assess the methodological and reporting quality of the CPGs. The extracted recommendations, including but not limited to screening, diagnosis, evaluation and treatment, will be summarized and analyzed, and the results will be presented in tabular form. Bubble charts will be used to show quality differences between CPGs and to describe the correlation between methodological and reporting quality through regression analysis. Excel, EndnoteX9 and SPSS 25.0 will be used.
To evaluate the advantages and disadvantages of the existing CPGs of osteoporosis and analyze the similarities and differences between the recommendations, the results will be published in a peer-reviewed journal.
This study will provide systematic evidence for existing CPGs of osteoporosis and to provide a reference for CPGs users.
INPLASY 202070031.
骨质疏松症是一种患病率高但治疗率低的疾病，对患者生命构成严重威胁，并带来沉重的经济负担。临床实践指南（CPG）为疾病管理提供重要指导。到目前为止，不同国家、地区和组织已发布了一定数量的骨质疏松症CPG，但不同指南中的建议并不一致。本方案计划评估骨质疏松症CPG的质量，然后对CPG中的建议进行比较分析。
将检索包括PubMed、Web of Science、Embase和Cochrane图书馆在内的多个数据库以及相关组织的官方网站。由两名审阅者独立进行筛选和数据提取，第三名审阅者协助解决他们之间的分歧。使用AGREE II工具和RIGHT清单评估CPG的方法学和报告质量。对提取的建议（包括但不限于筛查、诊断、评估和治疗）进行总结和分析，结果将以表格形式呈现。将使用气泡图展示CPG之间的质量差异，并通过回归分析描述方法学和报告质量之间的相关性。将使用Excel、EndnoteX9和SPSS 25.0。
为评估现有骨质疏松症CPG的优缺点并分析建议之间的异同，结果将发表在同行评审期刊上。
本研究将为现有骨质疏松症CPG提供系统证据，并为CPG使用者提供参考。
INPLASY 202070031。
