Duriez Philibert, Robichon Lauralee, Dardennes Roland, Lavoisy Guillaume, Grouselle Dominique, Epelbaum Jacques, Ramoz Nicolas, Gorwood Philip, Tolle Virginie, Viltart Odile
Institute of Psychiatry and Neuroscience of Paris (IPNP), Université de Paris, INSERM UMR-S 1266, F-75014 Paris, France.
GHU Paris Psychiatrie et Neurosciences, Hôpital Sainte-Anne, F-75014 Paris, France.
J Clin Med. 2020 Aug 28;9(9):2782. doi: 10.3390/jcm9092782.
Anorexia nervosa (AN) is a severe metabopsychiatric disorder characterised by caloric intake restriction and often excessive physical exercise. Our aim is to assess in female AN patients and in a rodent model, the co-evolution of physical activity and potential dysregulation of acyl-(AG) and desacyl-(DAG) ghrelin plasma concentrations during denutrition and weight recovery. AN inpatients were evaluated at inclusion (T0, = 29), half-(T1) and total (T2) weight recovery, and one month after discharge (T3, = 13). C57/Bl6 mice with access to a running wheel, were fed ad libitum or submitted to short-(15 days) or long-(50 days) term quantitative food restriction, followed by refeeding (20 days). In AN patients, AG and DAG rapidly decreased during weight recovery (T0 to T2), AG increased significantly one-month post discharge (T3), but only DAG plasma concentrations at T3 correlated negatively with BMI and positively with physical activity. In mice, AG and DAG both increased during short- and long-term food restriction. After 20 days of ad libitum feeding, DAG was associated to persistence of exercise alteration. The positive association of DAG with physical activity during caloric restriction and after weight recovery questions its role in the adaptation mechanisms to energy deprivation that need to be considered in recovery process in AN.
神经性厌食症（AN）是一种严重的代谢性精神疾病，其特征为热量摄入受限且常伴有过度体育锻炼。我们的目的是在女性AN患者和啮齿动物模型中，评估营养不良和体重恢复期间身体活动的共同演变以及酰基-（AG）和去酰基-（DAG）胃饥饿素血浆浓度的潜在失调情况。对AN住院患者在入组时（T0，n = 29）、体重恢复一半时（T1）和完全恢复时（T2）以及出院后一个月（T3，n = 13）进行评估。让可使用跑步轮的C57/Bl6小鼠自由进食，或进行短期（15天）或长期（50天）定量食物限制，随后再喂养（20天）。在AN患者中，体重恢复期间（T0至T2）AG和DAG迅速下降，出院后一个月（T3）AG显著升高，但仅T3时的DAG血浆浓度与BMI呈负相关且与身体活动呈正相关。在小鼠中，短期和长期食物限制期间AG和DAG均升高。自由进食20天后，DAG与运动改变的持续存在有关。热量限制期间和体重恢复后DAG与身体活动的正相关关系对其在能量剥夺适应机制中的作用提出了质疑，而这在AN恢复过程中需要加以考虑。
