Institute of Biomedical Informatics, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.
Int J Environ Res Public Health. 2020 Aug 28;17(17):6278. doi: 10.3390/ijerph17176278.
is an important gram-negative opportunistic pathogen that causes a variety of infectious diseases, including urinary tract infections, bacteremia, pneumonia, and liver abscesses. With the emergence of multidrug-resistant (MDR) and () strains, the rapid spread of these clinical strains in geography is particularly worrying. However, the detailed mechanisms of virulence and antibiotic resistance in are still not very clear. Therefore, studying and elucidating the pathogenic mechanisms and drug resistance mechanism of infection are important parts of current medical research. In this paper, we systematically summarized the virulence, biofilm, and antibiotic tolerance mechanisms of , and explored the application of whole genome sequencing and global proteomics, which will provide new clues for clinical treatment of .
是一种重要的革兰氏阴性机会性病原体,可引起多种传染病,包括尿路感染、菌血症、肺炎和肝脓肿。随着多药耐药(MDR)和()菌株的出现,这些临床菌株在地理上的迅速传播尤其令人担忧。然而,在的毒力和抗生素耐药性的详细机制仍不是很清楚。因此,研究和阐明感染的发病机制和耐药机制是当前医学研究的重要部分。在本文中,我们系统地总结了的毒力、生物膜和抗生素耐受机制,并探讨了全基因组测序和全球蛋白质组学的应用,这将为的临床治疗提供新的线索。