Centro de Análises Proteômicas e Bioquímicas, Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília, DF, Brazil.
S-inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, MS 79117-900, Brazil.
Future Microbiol. 2020 Jan;15:63-79. doi: 10.2217/fmb-2019-0180. Epub 2020 Feb 12.
is a Gram-negative pathogenic bacterium that has the ability to aggregate as biofilm, representing one of the main agents in hospital infections, showing high rates of resistance to antibiotics. The biofilm aggregates are composed mainly of extracellular polysaccharides, eDNA and proteins. Besides, biofilms can attach to medical devices, such as endotracheal tubes and catheters, but are most dangerous on body surfaces. Here, we discuss the recent findings about the resistance mechanisms of biofilms, including genes and protein involved in 'classic', multidrug-resistant and hypervirulent strains, and also virulence factors. In addition, we also explore new strategies for possible treatment of these biofilms, and recently discovered molecules which may lead to future treatments.
是一种革兰氏阴性的致病性细菌，具有聚集形成生物膜的能力，是医院感染的主要病原体之一，对抗生素的耐药率很高。生物膜聚集物主要由细胞外多糖、eDNA 和蛋白质组成。此外，生物膜可以附着在医疗设备上，如气管内管和导管，但在体表上最危险。在这里，我们讨论了生物膜耐药机制的最新发现，包括参与“经典”、多药耐药和高毒力菌株以及毒力因子的基因和蛋白质。此外，我们还探索了治疗这些生物膜的新策略，以及最近发现的可能导致未来治疗的分子。
