Molecular and Cellular Biology Laboratory, ICMR-National Institute for Research in Reproductive Health, Indian Council of Medical Research (ICMR), Mumbai, India.
Department of Microbiology, MGM Medical College, Navi Mumbai, India.
J Matern Fetal Neonatal Med. 2022 Aug;35(15):2923-2931. doi: 10.1080/14767058.2020.1813705. Epub 2020 Sep 1.
Preterm birth is a major cause of neonatal morbidity and mortality. Vaginal colonization of Group B Streptococci (GBS) is associated with increased risk of preterm birth. However, the association of GBS colonization and preterm births in the Indian context remains an unrecognized problem.
Data was collected using various online search tools from 36 (1981-2019) Indian studies comprising 9778 cases.
Studies reporting the prevalence of GBS colonization in the Indian population were included.
TABULATION, INTEGRATION, AND RESULTS: The prevalence of GBS colonization in pregnant Indian women was estimated to be 7.8% (763/9778) with wide heterogeneity across studies. The prevalence of GBS was 7.4% when culture methods were used and 11.6% with use of immunological methods. The detection rate of GBS almost doubled when enrichment was used in the culture method (8.1 vs. 5%). The risk of preterm delivery was higher (OR 7.9) among women with GBS colonization as compared to those without GBS.
As compared to the western population, there is low prevalence of GBS colonization among Indian pregnant women; however, the risk of preterm births with GBS colonization is higher. There is a need to implement a universal GBS screening program prior to intrapartum antibiotic prophylaxis in women experiencing preterm births.
早产是新生儿发病率和死亡率的主要原因。B 群链球菌（GBS）阴道定植与早产风险增加相关。然而，GBS 定植与印度早产之间的关联仍是一个未被认识到的问题。
使用各种在线搜索工具，从 36 项（1981 年至 2019 年）印度研究中收集数据，这些研究共包含 9778 例病例。
纳入报道印度人群中 GBS 定植率的研究。
列表、整合和结果：估计在印度孕妇中 GBS 定植的流行率为 7.8%（763/9778），各研究之间存在广泛的异质性。当使用培养方法时，GBS 的流行率为 7.4%，而当使用免疫学方法时，流行率为 11.6%。当在培养方法中使用富集时，GBS 的检出率几乎翻了一番（8.1%比 5%）。与没有 GBS 定植的女性相比，GBS 定植的女性早产风险更高（OR 7.9）。
与西方人群相比，印度孕妇中 GBS 定植的流行率较低；然而，GBS 定植与早产的风险较高。需要在经历早产的女性中实施普遍的 GBS 筛查计划，以替代产时抗生素预防。
